Laser Speckle Flowgraphy LSFG-NAVI

English Papers

Last Updated: 2024/10/28

Department of Ophthalmology, Hokkaido University

Hirose S, Saito W, Yoshida K, Saito M, Dong Z, Namba K, Satoh H, Ohno S.
Elevated choroidal blood flow velocity during systemic corticosteroidtherapy in Vogt-Koyanagi-Harada disease
Acta Ophthalmol. 2008 Dec;86(8):902-7. Epub 2008 Nov 12.
Michiyuki Saito, Kazuhiko Yoshida, Wataru Saito, Akio Fujiya, Kazuhiro Ohgami, Nobuyoshi Kitaichi, Hiroki Tsukahara, Susumu Ishida and Shigeaki Ohno
Astaxanthin increases choroidal blood flow velocity
Graefe's Archive for Clinical and Experimental Ophthalmology ,Vol.250, No.2, 239-245, DOI: 10.1007/s00417-011-1843-1, 2012.
Hashimoto Y, Saito W, Mori S, Saito M, Ishida S
Increased macular choroidal blood flow velocity during systemic corticosteroid therapy in a patient with acute macular neuroretinopathy
Clinical Ophthalmology, 2012:6, 1645-1649
Michiyuki Saito, Wataru Saito, Yuki Hashimoto, Chikako Yoshizawa, Akio Fujiya, Kousuke Noda, Susumu Ishida
Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy
Br J Ophthalmol doi:10.1136/bjophthalmol-2012-302349
Michiyuki Saito, Wataru Saito, Yuki Hashimoto, Chikako Yoshizawa, Yasuhiro Shinmei, Kousuke Noda, Susumu Ishida
Correlation between decreased choroidal blood flow velocity and the pathogenesis of acute zonal occult outer retinopathy
Clinical and Experimental Ophthalmology, DOI:10.1111/ceo.12143
Ai Takahashi, Wataru Saito, Yuki Hashimoto, Michiyuki Saito, Susumu Ishida
Impaired Circulation in the Thickened Choroid of a Patient with Serpiginous Choroiditis
Ocular Immunology and Inflammation, Posted online on April 11, 2014. doi:10.3109/09273948.2014.902075
Kiriko Hirooka, Wataru Saito, Kousuke Noda and Susumu Ishida
Enhanced-depth Imaging Optical Coherence Tomography and Laser Speckle Flowgraphy in a Patient with Acute Macular Neuroretinopathy
Ocular Immunology & Inflammation, (0), 1-5, 2014. doi:10.3109/09273948.2014.916305
Kiriko Hirooka, Wataru Saito, Yuki Hashimoto, Michiyuki Saito and Susumu Ishida
Increased macular choroidal blood flow velocity and decreased choroidal thickness with regression of punctate inner choroidopathy
BMC Ophthalmology, 14(1), 73, 2014.
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda and Susumu Ishida
Decreased choroidal blood flow velocity in the pathogenesis of multiple evanescent white dot syndrome
Graefe's Archive for Clinical and Experimental Ophthalmology, 2014, 1-8.
Kiriko Hirooka, Wataru Saito, Kenichi Namba, Yuko Takemoto, Kazuomi Mizuuchi, Tomoe Uno, Yoshiaki Tagawa, Yuki Hashimoto and Susumu Ishida
Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt–Koyanagi–Harada disease
Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, 1-9.
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda and Susumu Ishida
Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy
Japanese Journal of Ophthalmology, 2015, 1-9.
Michiyuki Saito, Wataru Saito, Kiriko Hirooka, Yuki Hashimoto, Shohei Mori, Kousuke Noda and Susumu Ishida
Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy
Investigative Ophthalmology & Visual Science, 56(11), 6515-6522, 2015.
Kiriko Hirooka, Wataru Saito , Michiyuki Saito, Yuki Hashimoto, Shohei Mori, Kousuke Noda and Susumu Ishida
Increased choroidal blood flow velocity with regression of acute posterior multifocal placoid pigment epitheliopathy
Japanese Journal of Ophthalmology, 2016, 1-7.
Yuko Takemoto, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Tomoe Uno, Shigeaki Ohno, Kiriko Hirooka, Yuki Hashimoto, Wataru Saito, Kazuhisa Sugiyama and Susumu Ishida
Choroidal circulation impairment during the anterior recurrence of Vogt–Koyanagi–Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy
Acta Ophthalmologica, 2016.
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa, Akari Takita, Shohei Mori, Kousuke Noda and Susumu Ishida
Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy
Journal of Ophthalmology, 2017.
Michiyuki Saito, Kousuke Noda, Wataru Saito and Susumu Ishida
Relationship between choroidal blood flow velocity and choroidal thickness in patients with regression of acute central serous chorioretinopathy
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s0041, 2017.
Akari Takita, Yuki Hashimoto, Wataru Saito, Satoru Kase and Susumu Ishida
Changes in blood flow velocity and thickness of the choroid in a patient with leukemic retinopathy
American journal of ophthalmology case reports, doi:10.1016/j.ajoc.2018.09.001, 2018.
Iku Kikuchi, Satoru Kase, Yuki Hashimoto, Kiriko Hirooka and Susumu Ishida
Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04257-7, 2019.
Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Yuka Hasegawa and Susumu Ishida
Increased thickness and decreased blood flow velocity of the choroid in a patient with acute macular neuroretinopathy
BMC Ophthalmology, 19:109, doi:10.1186/s12886-019-1123-0, 2019.
Wataru Saito, Susumu Ishida
Acute Zonal Occult Outer Retinopathy
Inflammatory and Infectious Ocular Disorders. Retina Atlas., doi:10.1007/978-981-13-8546-9_6, 2019.
Michiyuki Saito, Kousuke Noda, Wataru Saito, Kiriko Hirooka, Yuki Hashimoto and Susumu Ishida
Increased choroidal blood flow and choroidal thickness in patients with hypertensive chorioretinopathy
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04511-y, 2019.
Yuka Hasegawa, Yuki Hashimoto, Yasuhiro Shinmei and Susumu Ishida
Optic nerve head microcirculation in congenital nasal optic disc hypoplasia
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04540-7, 2019.
Wataru Saito, Yuki Hashimoto, Kiriko Hirooka and Susumu Ishida
Changes in choroidal blood flow velocity in patients diagnosed with central serous chorioretinopathy during follow-up for pachychoroid pigment epitheliopathy
American Journal of Ophthalmology Case Reports, doi:10.1016/j.ajoc.2020.100651, 2020.
Mizuho Mitamura, Satoru Kase and Susumu Ishida
Multimodal imaging in sclerochoroidal calcification: a case report and literature review
BMC Ophthalmology, 20(1), 1-5, doi:10.1186/s12886-020-01520-y, 2020.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka and Susumu Ishida
Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect
Oncotarget, 11(42), 3800-3804, doi:10.18632/oncotarget.27771, 2020.
Satoru Kase, Hiroaki Endo, Mitsuo Takahashi, Masahiko Yokoi, Yuki Ito, Satoshi Katsuta, Shozo Sonoda, Taiji Sakamoto, Susumu Ishida and Manabu Kase
Involvements of choroidal vascular structures with local treatments in patients with diabetic macular edema
European Journal of Ophthalmology, doi:10.1177/11206721211027103, 2021.
Yui Yamashita, Michiyuki Saito, Kiriko Hirooka and Susumu Ishida
Laser speckle flowgraphy findings in focal scleral nodule
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-021-05391-x, 2021.
Kiriko Hirooka, Michiyuki Saito, Yui Yamashita, Yuki Hashimoto, Nobuhiro Terao, Hideki Koizumi, Kousuke Noda and Susumu Ishida
Imbalanced choroidal circulation in eyes with asymmetric dilated vortex vein
Japanese Journal of Ophthalmology, 66(1), 14-18, doi:10.1007/s10384-021-00889-7, 2021.
Yui Yamashita, Yuki Hashimoto, Kenichi Namba, Kazuomi Mizuuchi and Susumu Ishida
Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
Case Reports in Ophthalmology, 12, 899-908, doi:10.1159/000520036, 2021.
Satoru Kase, Ayaka Hasegawa, Kiriko Hirooka, Hiroaki Endo, Kousuke Noda and Susumu Ishida
Laser speckle flowgraphy findings in a patient with radiation retinopathy
International Journal of Ophthalmology, 15(1), 172-174, doi:10.18240/ijo.2022.01.26, 2022.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Hiroaki Endo, Yuki Ito, Yuko Cho and Susumu Ishida
Alterations of choroidal circulation and vascular morphology in a patient with chronic myeloid leukemia before and after chemotherapy
BMC Ophthalmology, 22(1), 1-7, doi:10.1186/s12886-022-02380-4, 2022.
Tomoko Noda, Kousuke Noda, Kiriko Hirooka, Satoru Kase and Susumu Ishida
Subretinal fluid accumulation in a patient with polycythemia vera after receiving a prostaglandin I2 analogue treatment
American Journal of Ophthalmology Case Reports, doi:10.1016/j.ajoc.2022.101568, 2022.
Risako Sone, Kousuke Noda, Kiriko Hirooka, Michiyuki Saito and Susumu Ishida
Insidious progression of atrophic lesions in a case of posterior polar annular choroidal dystrophy
American Journal of Ophthalmology Case Reports, 28, 101708, doi:10.1016/j.ajoc.2022.101708, 2022.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka and Susumu Ishida
A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy
BMC Ophthalmology, 23(1), 180, doi:10.1186/s12886-023-02933-1, 2023.
Mizuho Mitamura, Satoru Kase, Kiriko Hirooka and Susumu Ishida
Alterations of choroidal circulation and choroidal thickness before and after chemoradiotherapy in a case of metastatic choroidal tumor
BMC Ophthalmology, 23(1), 270, doi:10.1186/s12886-023-03026-9, 2023.

Department of Ophthalmology, Sapporo Medical University

H.Tagawa, H. Furukawa and H. Fujii
Effect of topical timolol on the blood velocity of the iris microcirculation and the aqueous veins
Invest Ophthalmol Vis. Sci. 1993, 34(Suppl): 927
H.Tagawa, H. Furukawa and H. Fujii
Dynamic Ocular Blood Flow Image Using Laser Speckle Flowgraphy
Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995.
Hiroshi Tagawa, Hideki Furukawa and Hitoshi Fujii
Changes of Blood Circulation in Human Eyes with Retinal Diseases Using Real-Time Laser Flowgraphy
Proc. 3rd Internet World Congress on Biomedical Sciences, 1996
Tagawa H, Kawaguchi S,Furukawa H, and Fujii H.
Effect of retrobulbar injection of unoprostone on the rabbit ocular microcirculation
Invest Ophthalmol Vis Sci 1997, 38(Suppl): 782
Kawaguchi S, Tagawa H, Maeda T, Suzuki J, and Fujii H.
Circulatory changes of retinal vessels and choroidal microcirculation in eyes with arterial occlusive disease
Invest Ophthalmol Vis Sci 1997, 38(Suppl): 1047
Tagawa H, Nakagawa H,Furukawa H, and Fujii H.
Visualization and quantitative evaluation of pulsatile ocular microcirculation by laser speckle flowgraphy
Invest Ophthalmol Vis Sci 1998, 39(Suppl): 267
Sasaki N, Tagawa H, Katsuta S, Nakagawa T andFujii H.
Long term effects of oral prostaglandin on retinal artery, optic nerve head, and choroidal micricirculation in normals
Invest Ophthalmol Vis Sci 1998, 39(Suppl): 271
Tashimo A,Tagawa H, Kawaguchi S, Suzuki T, Nakagawa T and Fujii H.
Effects of oral prostaglandin on retinal artery, optic nerve head, and choroidal micricirculation in eyes with arterial occlusive disease
Invest Ophthalmol Vis Sci 1998, 39(Suppl): 999
Katsuta S, Tagawa H, Suzuki T, Sasaki N, Nakagawa T and Fujii H.
Short term effects of oral prostaglandin on retinal artery, optic nerve head, and choroidal micricirculation in normals
Invest Ophthalmol Vis Sci 1998, 39(Suppl): 1000
Tagawa H,Sasaki N,Tashimo A, Suzuki T, Shimizu M, Fujii H.
Estimation of real blood velocity measured by laser speckle flowgraphy at retinal vessels
Invest Ophthalmol Vis Sci 1999, 40(Suppl): 369
Sasaki N, Tagawa H, Shimizu M, Suzuki T, Fujii H.
Changes of pulsatility at retinal arteries as aging
Invest Ophthalmol Vis Sci 1999, 40(Suppl): 488
Katsuta S,Shimizu M, Tagawa H, Sasaki N, Suzuki T, Fujii H.
Changes of pulsatility at choroidal microcirculation as aging
Invest Ophthalmol Vis Sci 1999, 40(Suppl): 488
Tashimo A, Tagawa H, Sasaki N, Suzuki T, Fujii H.
Changes of pulsatility at retinal arteries and choroidal microcirculation in patients with arteriosclerosis
Invest Ophthalmol Vis Sci 1999, 40(Suppl): 681
Kimihito Maeda, Futoshi Ishikawa, Hiroshi Ohguro
Ocular blood flow levels and visual prognosis in a patient with nonischemic type central retinal vein occlusion
Clinical Ophthalmology 2009:3 489-491
Hiroshi Ohguro, Ikuyo Ohguro, Maki Katai, Sachie Tanaka
Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma
Ophthalmologica(DOI: 10.1159/000335961), 2012.
Ikuyo Ohguro, Hiroshi Ohguro
The Effects of a Fixed Combination of 0.5% Timolol and 1% Dorzolamide on Optic Nerve Head Blood Circulation
Journal of Ocular Pharmacology and Therapeutics (doi:10.1089/jop.2011.0243.), 2012.
Fumihito Hikage, Masato Furuhashi, Yosuke Ida, Hiroshi Ohguro, Megumi Watanabe, Soma Suzuki and Kaku Itoh
Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion
PLOS ONE, 16(1), e0245763, doi:10.1371/journal.pone.0245763, 2021.
Kaku Itoh, Masato Furuhashi, Yosuke Ida, Hiroshi Ohguro, Megumi Watanabe, Soma Suzuki and Fumihito Hikage
Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy
Scientific Reports, 11(1), 1-10, doi:10.1038/s41598-021-91857-1, 2021.

Department of Cardiac Surgery, Asahikawa Medical University

Fumiaki Kimura, Hirotsugu Kanda, Yuki Toyama, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida, Hiroto Kitahara and Hiroyuki Kamiya
Evaluation of cerebral circulation during retrograde perfusion by laser speckle flowgraphy
General Thoracic and Cardiovascular Surgery, doi:10.1007/s11748-016-0727-z, 2016.
Hiroto Kitahara, Hirotsugu Kanda, Fumiaki Kimura, Tomohiro Takeda, Shingo Kunioka, Takayuki Kunisawa and Hiroyuki Kamiya
Cerebral circulation estimated by laser speckle flowgraphy in retrograde femoral arterial perfusion during minimally invasive cardiac surgery.
Interactive cardiovascular and thoracic surgery, 25(1), 25-29, doi:10.1093/icvts/ivx046, 2017.

Department of Anesthesiology and Critical care, Asahikawa Medical University

Hirotsugu Kanda, Fumiaki Kimura, Takafumi Iida, Megumi Kanao-Kanda, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida and Hiroyuki Kamiya
Combined Use of Intra-aortic Balloon Pump and Venoarterial Extracorporeal Membrane Oxygenation Support With Femoral Arterial Cannulation Impairs Cerebral Microcirculation: Evaluation With Laser Speckle Flowgraphy
Journal of Cardiothoracic and Vascular Anesthesia, doi:10.1053/j.jvca.2016.09.012, 2016.
Hirotsugu Kanda, Hiroto Kitahara, Yuki Toyama, Megumi Kanao-Kanda, Takayuki Kunisawa and Hiroyuki Kamiya
Intra-aortic Balloon Pump Does Not Impede Cerebral Microcirculation During Central Extracorporeal Membrane Oxygenation Support: Evaluation With Laser Speckle Flowgraphy
Journal of Cardiothoracic and Vascular Anesthesia, 31(4), e67-e68, doi:10.1053/j.jvca.2017.04.030, 2017.
Hirotsugu Kanda, TakayukiKunisawa, Hiroto Kitahara, Takafumi Iida, Yuki Toyama, Megumi Kanao-Kanda, Chie Mori and Hiroyuki Kamiya
Cerebral Hypoxia Caused by Flow Confliction During Minimally Invasive Cardiac Surgery With Retrograde Perfusion: A Word of Caution
Journal of Cardiothoracic and Vascular Anesthesia, 32(4), 1838-1840, doi:10.1053/j.jvca.2017.10.007, 2017.
Hirotsugu Kanda, Takayuki Kunisawa, Takafumi Iida, Masahiro Tada, Fumiaki Kimura, Hayato Ise and Hiroyuki Kamiya
Cerebral circulation during retrograde cerebral perfusion: evaluation using laser speckle flowgraphy
The Annals of Thoracic Surgery, doi:10.1016/j.athoracsur.2018.11.067, 2018.
Megumi Kanao-Kanda, Hirotsugu Kanda, Takafumi Iida, Shinsuke Kikuchi and Nobuyoshi Azuma
Clinical Application of Laser Speckle Flowgraphy to Assess Changes in Blood Flow to the Foot After a Lumbar Sympathetic Ganglion Block: A Case Report
Journal of Pain Research, 14, 1451-1456, doi:10.2147/JPR.S305543, 2021.

Department of Ophthalmology, Tohoku University

Naoko Aizawa, Yu Yokoyama, Naoki Chiba, Kazuko Omodaka, Masayuki Yasuda, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Toru Nakazawa
Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
Clinical Ophthalmology, 2011:5, 1171-1176
Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa
Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
Clinical Ophthalmology, 2011:5, 1549-1556
Yu Yokoyama, Naoko Aizawa, Naoki Chiba, Kazuko Omodaka, Masahiko Nakamura, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa
Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk
Clinical Ophthalmology, 2011:5, 1721 - 1727
Tsuda, Satoru MD; Yokoyama, Yu MD; Chiba, Naoki MD; Aizawa, Naoko MD; Shiga, Yukihiro MD; Yasuda, Masayuki MD; Yokokura, Shunji PhD, MD; Otomo, Takaaki MD; Fuse, Nobuo PhD, MD; Nakazawa, Toru PhD, MD
Effect of Topical Tafluprost on Optic Nerve Head Blood Flow in Patients With Myopic Disc Type
Journal of Glaucoma, POST AUTHOR CORRECTIONS, 2 April 2013, doi: 10.1097/IJG.0b013e318237c8b3
Naoko Aizawa, Hiroshi Kunikata, Yu Yokoyama and Toru Nakazawa
Correlation between optic disc microcirculation in glaucoma measured with laser speckle flowgraphy and fluorescein angiography, and the correlation with mean deviation
Clinical and experimental ophthalmology, 42(3), 293-294, doi:10.1111/ceo.12130, 2013.
Yukihiro Shiga, Masahiko Shimura, Toshifumi Asano, Satoru Tsuda, Yu Yokoyama, Naoko Aizawa,
Kazuko Omodaka, Morin Ryu, Shunji Yokokura, Takayuki Takeshita and Toru Nakazawa
The Influence of Posture Change on Ocular Blood Flow in Normal Subjects, Measured by Laser Speckle Flowgraphy
Current Eye Research, June 2013, Vol. 38, No. 6 , Pages 691-698 (doi:10.3109/02713683.2012.758292)
Yukihiro Shiga, Kazuko Omodaka, Hiroshi Kunikata, Morin Ryu, Yu Yokoyama, Satoru Tsuda, Toshifumi Asano, Shigeto Maekawa, Kazuichi Maruyama, Toru Nakazawa
Waveform analysis of ocular blood flow and the early detection of normal-tension glaucoma
IOVS, October 15, 2013 IOVS-13-12930(doi:10.1167/iovs.13-12930)
Shin Takayama, Yukihiro Shiga, Taiki Kokubun, Hideyuki Konno, Noriko Himori, Morin Ryu, Takehiro Numata, Soichiro Kaneko, Hitoshi Kuroda, Junichi Tanaka, Seiki Kanemura, Tadashi Ishii, Nobuo Yaegashi, Toru Nakazawa
The traditional kampo medicine tokishakuyakusan increases ocular blood flow in healthy subjects
Evidence-Based Complementary and Alternative Medicine, 2014.
Satoru Tsuda, Hiroshi Kunikata, Masahiko Shimura, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Yu Yokoyama, Toru Nakazawa
Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy
Current Eye Research, Posted online on April 21, 2014. (doi:10.3109/02713683.2014.905608)
Yukihiro Shiga, Toshifumi Asano, Hiroshi Kunikata, Fumihiko Nitta, Hajime Sato, Toru Nakazawa and Masahiko Shimura
Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy
Investigative Ophthalmology & Visual Science, IOVS-14, 2014. (doi: 10.1167/iovs.14-14116)
Fumihiko Nitta, Hiroshi Kunikata, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda and Toru Nakazawa
The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy
Clinical Ophthalmology, 2014:8, 1119 - 1127
Shunsuke Omodaka, Hidenori Endo, Hiroshi Doi, Hiroaki Shimizu, Miki Fujimura, Naoko Aizawa, Toru Nakazawa and Teiji Tominaga
Usefulness of Laser Speckle Flowgraphy for the Assessment of Ocular Blood Flow in Extracranial Intracranial Bypass
Journal of Stroke and Cerebrovascular Diseases (2014).
Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Yu Yokoyama, Kazuko Omodaka and Toru Nakazawa
Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy.
BMC Ophthalmology, 14(1), 113.
Naoko Aizawa, Fumihiko Nitta, Hiroshi Kunikata, Tetsuya Sugiyama, Tsunehiko Ikeda, Makoto Araie and Toru Nakazawa
Laser speckle and hydrogen gas clearance measurements of optic nerve circulation in albino and pigmented rabbits with or without optic disc atrophy.
Investigative Ophthalmology & Visual Science, IOVS-14, 2014. doi: 10.1167/iovs.14-15373
Wataru Kobayashi, Hiroshi Kunikata, Kazuko Omodaka, Kyousuke Togashi, Morin Ryu, Masahiro Akiba, Gaku Takeuchi, Tetsuya Yuasa, and Toru Nakazawa
Correlation of Optic Nerve Microcirculation with Papillomacular Bundle Structure in Treatment Naive Normal Tension Glaucoma
Journal of Ophthalmology, vol. 2014, Article ID 468908, 9 pages, 2014. doi:10.1155/2014/468908
Hiroshi Kunikata, Naoko Aizawa, Masataka Kudo, Shunji Mugikura, Fumihiko Nitta, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Fumitoshi Satoh, Hidetoshi Takahashi, Sadayoshi Ito, Shoki Takahashi and Toru Nakazawa
Relationship of Ocular Microcirculation, Measured by Laser Speckle Flowgraphy, and Silent Brain Infarction in Primary Aldosteronism
PLOS ONE, 10(2), e0117452, 2015.
Noriko Himori, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi and Toru Nakazawa
The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma
Graefe's Archive for Clinical and Experimental Ophthalmology, 1-9, 2015.
Hiroshi Kunikata, Toru Nakazawa
Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease.
The Asia-Pacific Journal of Ophthalmology, 2015
Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Yukihiro Shiga, Kazuko Omodaka, Satoru Tsuda and Toru Nakazawa
Age-and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation.
PLOS ONE, 11(2), e0148812, 2016.
Toru Nakazawa
Ocular Blood Flow and Influencing Factors for Glaucoma.
The Asia-Pacific Journal of Ophthalmology, 5(1), 38-44, 2016.
Maki Inoue, Noriko Himori, Hiroshi Kunikata, Takayuki Takeshita, Naoko Aizawa, Yukihiro Shiga,Kazuko Omodaka, Koji M Nishiguchi, Hidetoshi Takahashi and Toru Nakazawa
The reduction of temporal optic nerve head microcirculation in autosomal dominant optic atrophy
Acta ophthalmologica, 94(7), e580-e585, doi:10.1111/aos.12999, 2016.
Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Tsutomu Kikawa, Noriko Himori, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Akiba and Toru Nakazawa
Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography
PLOS ONE, 11(4), e0153707, 2016.
Kazuki Hashimoto, Hiroshi Kunikata, Masayuki Yasuda, Azusa Ito, Naoko Aizawa, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Yoshimasa Takano, Koji M. Nishiguchi, Hideki Katagiri and Toru Nakazawa
The relationship between advanced glycation end products and ocular circulation in type 2 diabetes
Journal of Diabetes and its Complications, 2016.
Yukihiro Shiga, Hiroshi Kunikata, Naoko Aizawa, Naoki Kiyota, Yukiko Maiya, Yu Yokoyama, Kazuko Omodaka, Hidetoshi Takahashi, Tomoki Yasui, Keiichi Kato, Aiko Iwase and Toru Nakazawa
Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma
Current Eye Research, doi:10.3109/02713683.2015.1127974, 2016.
Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-017-3627-8, 1-10, 2017.
Naoki Kiyota, Yukihiro Shiga, Shiori Suzuki, Marika Sato, Naoko Takada, Shigeto Maekawa, Kazuko Omodaka, Kazuichi Maruyama, Hiroshi Kunikata and Toru Nakazawa
The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Primary Open-Angle Glaucoma Patients
Investigative Ophthalmology and Visual Science, 58(7), 3181-3188, doi: 10.1167/iovs.17-21648, 2017.
Kazuichi Maruyama, Aya Noguchi, Ai Shimizu, Yukihiro Shiga, Hiroshi Kunikata and Toru Nakazawa
Predictors of Recurrence in Vogt-Koyanagi-Harada Disease
Ophthalmology Retina, doi: 10.1016/j.oret.2017.07.016, 2017.
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal-tension glaucoma with myopic disc
Acta Ophthalmologica, doi:10.1111/aos.13621, 2017.
Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto and Toru Nakazawa
Preperimetric Glaucoma Prospective Observational Study (PPGPS): Design, baseline characteristics, and therapeutic effect of tafluprost in preperimetric glaucoma eye
PLOS ONE, 12(12), e0188692, doi:10.1371/journal.pone.0188692, 2017.
Yukihiro Shiga, Koji M. Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa , for the Japan Glaucoma Society Omics Group (JGS-OG)
Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7.
PloS one, 12(12), e0186678, doi:10.1371/journal.pone.0186678, 2017.
Kazuko Omodaka, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba and Toru Nakazawa
Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters
PloS one, 12(12), e0190012, doi:10.1371/journal.pone.0190012, 2017.
Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Hiroshi Kunikata, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto and Toru Nakazawa
Preperimetric Glaucoma Prospective Study (PPGPS): Predicting Visual Field Progression With Basal Optic Nerve Head Blood Flow in Normotensive PPG Eyes
Translational vision science and technology, 7(1), 11, doi:10.1167/tvst.7.1.11, 2018.
Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma.
Acta Ophthalmologica, doi:10.1111/aos.13639, 2018.
Naoki Kiyota, Yukihiro Shiga, Kohei Ichinohasama, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Naoto Honda, Hiroshi Kunikata and Toru Nakazawa
The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow
Investigative Ophthalmology & Visual Science, 59(8), 3488-3496, 2018.
Maki Inoue-Yanagimachi, Noriko Himori, Kota Sato, Taiki Kokubun, Toshifumi Asano, Yukihiro Shiga, Satoru Tsuda, Hiroshi Kunikata and Toru Nakazawa
Association between mitochondrial DNA damage and ocular blood flow in patients with glaucoma
British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2018-312356, 2018.
Kohei Ichinohasama, Hiroshi Kunikata, Azusa Ito, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Hideki Katagiri and Toru Nakazawa
The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes
Journal of Ophthalmology, doi:10.1155/2019/3421305, 2019.
Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata and Toru Nakazawa
Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression
Investigative Ophthalmology & Visual Science, 60(7), 2650-2658, doi:10.1167/iovs.19-27230, 2019.
Toru Nakazawa, Takeo Fukuchi
What is glaucomatous optic neuropathy?
Japanese Journal of Ophthalmology, 64(3), 243–249, doi:10.1007/s10384-020-00736-1, 2020.
Toshifumi Asano, Hiroshi Kunikata, Masayuki Yasuda, Koji M. Nishiguchi, Toshiaki Abe and Toru Nakazawa
Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab
International Ophthalmology, doi:10.1007/s10792-020-01562-7, 2020.
Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Kyongsun Pak and Toru Nakazawa
Time-course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma
Ophthalmology, doi:10.1016/j.ophtha.2020.10.010, 2020.
Masayuki Yasuda, Hajime Sato, Kazuki Hashimoto, Urara Osada, Takehiro Hariya, Hiroko Nakayama, Toshifumi Asano, Noriyuki Suzuki, Tatsu Okabe, Mai Yamazaki, Megumi Uematsu, Masanori Munakata and Toru Nakazawa
Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion
PloS one, 15(10), e0240977, doi:10.1371/journal.pone.0240977, 2020.
Nana Takahashi, Hiroshi Kunikata, Masayuki Yasuda, Takehiro Hariya, Koji M. Nishiguchi and Toru Nakazawa
Polypoidal choroidal vasculopathy in a case of retinitis pigmentosa, successfully treated with intravitreal aflibercept
American Journal of Ophthalmology Case Reports, 101123, doi:10.1016/j.ajoc.2021.101123, 2021.
Chiaki Yamaguchi, Hiroshi Kunikata, Kazuki Hashimoto, Masaaki Yoshida, Takahiro Ninomiya, Takehiro Hariya, Toshiaki Abe and Toru Nakazawa
De novo Vogt-Koyanagi-Harada disease after vaccination for COVID-19, successfully treated with systemic steroid therapy and monitored with laser speckle flowgraphy
American Journal of Ophthalmology Case Reports, 101616, doi:10.1016/j.ajoc.2022.101616, 2022.
Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka and Toru Nakazawa
The relationship between choroidal blood flow and glaucoma progression in a Japanese study population
Japanese Journal of Ophthalmology, doi:10.1007/s10384-022-00929-w, 2022.
Masataka Sato, Masayuki Yasuda, Nana Takahashi, Kazuki Hashimoto, Noriko Himori and Toru Nakazawa
Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma
PLOS ONE, 18(2), e0282047, doi:10.1371/journal.pone.0282047, 2023.
Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori and Toru Nakazawa
Factors Associated With Visual Acuity Decline in Glaucoma Patients With Loss of Ganglion Cell Complex Thickness
Translational Vision Science and Technology, 12(7), 2, doi:10.1167/tvst.12.7.2, 2013.
Nana Takahashi, Naoki Kiyota, Hiroshi Kunikata, Mai Yamazaki, Takayuki Nishimura, Yukihiro Shiga, Hisae Aoyagi, Miwako Shidomi, Tomohiro Tsuda, Toshihiko Ohtsuka, Takahiro Tomida and Toru Nakazawa
Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients
BMC Ophthalmology, 23(1), 1-11, doi:10.1186/s12886-023-03059-0, 2023.

Department of Obstetrics and Gynecology, Tohoku University

Takahiro Sato, Junichi Sugawara , Naoko Aizawa, Noriyuki Iwama, Fumiaki Takahashi, Michiyo Nakamura-Kurakata, Masatoshi Saito, Takashi Sugiyama, Hiroshi Kunikata, Toru Nakazawa and Nobuo Yaegashi
Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy
PLOS ONE, 12(3), e0173127, doi:10.1371/journal.pone.0173127, 2017.

Department of Ophthalmology, Akita University

Yusuke Ohta, Sanae Takaseki and Takeshi Yoshitomi
Effects of ripasudil hydrochloride hydrate (K-115), a Rho-kinase inhibitor, on ocular blood flow and ciliary artery smooth muscle contraction in rabbits
Japanese journal of ophthalmology, 61(5), 423–432, 2017.
Ya-Ru Dong, Shi-Wei Huang, Ji-Zhe Cui and Takeshi Yoshitomi
Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo
International Journal of Ophthalmology, 11(5), 719–725, 2018.
Takeshi Iwase, Yoshitaka Ueno, Ryo Tomita and Hiroko Terasaki
Relationship Between Retinal Microcirculation and Renal Function in Patients with Diabetes and Chronic Kidney Disease by Laser Speckle Flowgraphy
Life, 13(2), 424, doi:10.3390/life13020424, 2023.

Department of Ophthalmology, Gunma University

Hiroaki Isono, Shoji Kishi, Yasutaka Kimura, Naoya Hagiwara, Naoki Konishi and Hitoshi Fujii
Observation of Choroidal Circulation Using Index of Erythrocytic Velocity
Arch Ophthalmol, 121, no.2, 225-231, 2003.
A. Otsubo, S. Kishi, K. Ohkoshi and T. Ymaguchi
The Influence of Peripheral Retinal Detachment in Choroidal Blood Flow of the Macula
ARVO, 2003, (3004/B843)
Watanabe G, Fujii H, Kishi S
Imaging of Choroidal Hemodynamics in Eyes with Polypoidal Choroidal Vasculopathy Using Laser Speckle Phenomenon
Jpn J Ophthalmol 52: 204-210, 2008
Yoichiro Shinohara, Tomoyuki Kashima, Hideo Akiyama, Shoji Kishi
Alteration of choroidal thickness in a case of carotid cavernous fistula: a case report and a review of the literature
BMC Ophthalmology 2013, 13:75 doi:10.1186/1471-2415-13-75
Yoichiro Shinohara, Tomoyuki Kashima, Hideo Akiyama, Yukitoshi Shimoda, Danjie Li and Shoji Kishi
Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy
PLOS ONE, 12(1), e0169596, 2017.

Department of Neurosurgery, Saitama Medical Center, Saitama Medical University

Shinsuke Yoshida, Soichi Oya, Hiroto Obata, Naoaki Fujisawa, Tsukasa Tsuchiya, Takumi Nakamura, Masahiro Indo, Masaaki Shojima and Toru Matsui
Carotid endarterectomy restores decreased vision due to chronic ocular ischemia
Acta Neurochir, doi:10.1007/s00701-020-04603-3, 2020.

Department of Ophthalmology, Niigata University

Kiyoshi Yaoeda, Motohiro Shirakashi, Shigeo Funaki, Haruko Funaki, Tomoko Nakatsue, Atsushi Fukushima
Measurement of Microcirculation in the Optic Nerve Head by Laser Speckle Flowgraphy and Scanning Laser Doppler Flowmetry.
Am. J. Ophthalmol., 129, NO. 6, 734-739, 2000.
Kiyoshi Yaoeda, Motohiro Shirakashi, Shigeo Funaki, Haruko Funaki, Tomoko Nakatsue, Atsushi Fukushima AND Haruki Abe
Measurement of Microcirculation in Optic Nerve Head by Laser Speckle Flowgraphy in Normal Volunteers
Am. J. Ophthalmol., 130, NO. 5, 606-610, 2000.
Kiyoshi Yaoeda, Motohiro Shirakashi, Atsushi Fukushima, Shigeo Funaki, Haruko Funaki, Haruki Abe and Naohito Tanabe
Relationship between optic nerve head microcirculation and visual field loss in glaucoma.
Acta Ophthalmol. Scand, 81, 253-259, 2003.

Department of Ophthalmology, University of Toyama

Yuta Takata, Yasuhito Nitta, Akio Miyakoshi and Atsushi Hayashi
Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion
Case Reports in Ophthalmology, 9(2), 327-332, doi:10.1159/000489696, 2018.
Shinya Abe, Tomoko Nakamura, Erika Okumura, Toshihiko Oiwake, Annabelle A. Okada and Atsushi Hayashi
Long-term changes of choroidal blood flow velocity in Vogt-Koyanagi-Harada disease
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-021-05540-2, 2022.

Department of Ophthalmology, Toho University Sakura Medical Center

Tomoaki Shiba, Mao Takahashi, Yuichi Hori and Takatoshi Maeno
Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachialankle pulse-wave velocity, carotid intima media thickness, and age
Graefe's Archive for Clinical and Experimental Ophthalmology (DOI: 10.1007/s00417-012-1952-5), 2012.
Shiba T, Takahashi M, Hori Y, Maeno T, Shirai K.
Optic Nerve Head Circulation Determined by Pulse Wave Analysis is Significantly Correlated with Cardio Ankle Vascular Index, Left Ventricular Diastolic Function, and Age.
Journal of atherosclerosis and thrombosis, Published online: July 4, 2012.
Tomoaki Shiba, Mao Takahashi, Takatoshi Maeno
Pulse-Wave Analysis of Optic Nerve Head Circulation Is Significantly Correlated With Kidney Function in Patients With and Without Chronic Kidney Disease
Journal of Ophthalmology, 2013.
Makoto Ubuka, Tetsuya Sugiyama, Yasutaka Onoda, Tomoaki Shiba, Yuichi Hori, Takatoshi Maeno
Changes in the Blood Flow of the Optic Nerve Head Induced by Different Concentrations of Epinephrine in Intravitreal Infusion During Vitreous Surgery
Investigative Ophthalmology & Visual Science, 2014, IOVS-13-13801.
Muramatsu Rina, Tomoaki Shiba, Mao Takahashi, Yuichi Hori and Takatoshi Maeno
Pulse waveform analysis of optic nerve head circulation for predicting carotid atherosclerotic changes.
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-015-3123-y, 2015.
Ryuya Hashimoto, Asato Hirota and Takatoshi Maeno
Choroidal blood flow impairment demonstrated using laser speckle flowgraphy in a case of commotio retinae
American Journal of Ophthalmology Case Reports, doi: 10.1016/j.ajoc.2016.08.002, 2016.
Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka and Takatoshi Maeno
Autoregulation of Optic Nerve Head Blood Flow Induced by Elevated Intraocular Pressure during Vitreous Surgery.
Current Eye Research, doi: 10.1080/02713683.2016.1220592, 2016.
Ryuya Hashimoto, Tetsuya Sugiyama, Hidetaka Masahara, Masashi Sakamoto, Makoto Ubuka and Takatoshi Maeno
Impaired Autoregulation of Blood Flow at the Optic Nerve Head during Vitrectomy in Patients with Type 2 Diabetes
American Journal of Ophthalmology, doi: 10.1016/j.ajo.2017.06.021, 2017.
Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka and Takatoshi Maeno
Impairment of autoregulation of optic nerve head blood flow during vitreous surgery in patients with hypertension and hyperlipidemia
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-017-3788-5, 2017.
Ryuya Hashimoto, Juri Kawamura, Asato Hirota, Mizuho Oyamada, Asao Sakai and Takatoshi Maeno
Changes in choroidal blood flow and choroidal thickness after treatment in two cases of pediatric anisohypermetropic amblyopia
American Journal of Ophthalmology Case Reports, Volume 8, 39-43, doi: 10.1016/j.ajoc.2017.10.010, 2017.
Ryuya Hashimoto, Tetsuya Sugiyama and Takatoshi Maeno
Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy
BioMed Research International, vol. 2017, Article ID 6041590, 6 pages, doi:10.1155/2017/6041590, 2017.
Ryuya Hashimoto, Mizuho Oyamada and Takatoshi Maeno
Analysis of Optic Nerve Head Circulation Using Laser Speckle Flowgraphy in a Case of Pediatric Optic Neuritis
EC Ophthalmology, 9(8), 572-581, 2018.
Ryo Yamazaki, Ryuya Hashimoto, Hidetaka Masahara, Masashi Sakamoto and Takatoshi Maeno
Time Course in Ocular Blood Flow and Pulse Waveform in a Case of Ocular Ischemic Syndrome with Intraocular Pressure Fluctuation
Vision, 4(2), 31, doi:10.3390/vision4020031, 2020.
Keisuke Yata, Ryuya Hashimoto, Hidetaka Masahara, Mizuho Oyamada and TakatoshiMaeno
Changes in choroidal circulation and pulse waveform in a case of pregnancy-induced hypertension with serous retinal detachment
American Journal of Ophthalmology Case Reports, 100911, doi:10.1016/j.ajoc.2020.100911, 2020.
Takatoshi Maeno, Kenichiro Aso, Ryuya Hashimoto and Hidetaka Masahara
Improving blood flow in occluded veins to reduce anti-vascular endothelial growth factor injections for branch retinal vein occlusion
American Journal of Ophthalmology Case Reports, 30, 101847, doi:10.1016/j.ajoc.2023.101847, 2023.
Takatoshi Maeno, Ryuya Hashimoto, Sonoko Isa, Keisuke Yata and Hidetaka Masahara
Time course of choroidal blood flow during anti-VEGF treatment for pachychoroid disease
Investigative Ophthalmology and Visual Science, 64(8), 1995, 2023 ARVO Annual Meeting abstract, 2023.

Department of Ophthalmology, Toho University Omori Medical Center

Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Yuuji Katayama, Tetsushi Arimura, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
Reproducibility of Neonate Ocular Circulation Measurements using Laser Speckle Flowgraphy
BioMed Research International, 2015.
Tomoaki Shiba, Tetsuya Sugiyama, Yuichi Hori, Tadashi Matsumoto, Takatoshi Maeno and Mao Takahashi
Relationship between plasma levels of vasoactive mediators and optic nerve head circulation shown by laser speckle flowgraphy
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-015-3145-5, 2015.
Tomoaki Shiba , Mao Takahashi, Ryuya Hashimoto, Tadashi Matsumoto and Yuichi Hori
Pulse waveform analysis in the optic nerve head circulation reflects systemic vascular resistance obtained via a Swan–Ganz catheter.
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3289-y, 2016.
Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Yuuji Katayama, Tetsushi Arimura, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
Ocular blood flow values measured by laser speckle flowgraphy correlate with the postmenstrual age of normal neonates
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3362-6, 2016.
Chieko Shiba, Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
Relationship between glycosylated hemoglobin A1c and ocular circulation by laser speckle flowgraphy in patients with/without diabetes mellitus
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3437-4, 2016.
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Kohji Shirai and Yuichi Hori
Arterial stiffness shown by the cardio-ankle vascular index is an important contributor to optic nerve head microcirculation
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-016-3521-9, 2016.
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori and Kohji Shirai
Arterial Stiffness, Monitored with Cardio Ankle Vascular Index is Adjusting The Ocular Microcirculation Obtained from Laser Speckle Flowgraphy.
Journal of Hypertension, doi: 10.1097/01.hjh.0000501307.42081.00, 2016.
Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Kotaro Hine and Yuichi Hori
A Change in Ocular Circulation after Photocoagulation for Retinopathy of Prematurity in a Neonate
Case Reports in Ophthalmology, 8(1), 91-98, doi: 10.1159/000456708, 2017.
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
Differences in optic nerve head microcirculation between evening and morning in patients with coronary artery disease
Microcirculation, doi: 10.1111/micc.12386, 2017.
Tadashi Matsumoto, Yuta Saito, Takashi Itokawa, Tomoaki Shiba, Mari S. Oba, Haruo Takahashi and Yuichi Hori
Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-017-3756-0, 2017.
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
Relationship between Metabolic Syndrome and Ocular Microcirculation Shown by Laser Speckle Flowgraphy in a Hospital Setting Devoted to Sleep Apnea Syndrome Diagnostics
Journal of Diabetes Research, doi: 10.1155/2017/3141678, 2017.
Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Masahiko Tomita, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
Decreased ocular blood flow after photocoagulation therapy in neonatal retinopathy of prematurity
Japanese journal of ophthalmology, doi: 10.1007/s10384-017-0536-7, 2017.
Hironori Osamura, Tomoaki Shiba, Takashi Itokawa, Tadashi Matsumoto and Yuichi Hori
Relationships among Ocular Blood Flow Shown by Laser Speckle Flowgraphy, Retinal Arteriosclerotic Change, and Chorioretinal Circulation Time Obtained by Fluorescein Angiography
Journal of Ophthalmology, doi: 10.1155/2017/2969064, 2017.
Tomoaki Shiba, Mao Takahashi, Chieko Shiba, Tadashi Matsumoto and Yuichi Hori
The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass
The International Journal of Cardiovascular Imaging, doi: 10.1007/s10554-018-1388-z, 2018.
Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Masahiko Tomita, Kotaro Hine, Norio Mizukaki, Hitoshi Yoda and Yuichi Hori
Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-018-4063-0, 2018.
Tetsushi Arimura, Tomoaki Shiba, Mao Takahashi, Shun Kumashiro, Hironori Osamura. Tadashi Matsumoto, Ken Sakai and Yuichi Hori
Assessment of ocular microcirculation in patients with end-stage kidney disease
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-018-4137-z, 2018.
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction
Journal of vascular research, 55(6), 329-337, doi:10.1159/000494066, 2018.
Tatsuhiko Kobayashi, Tomoaki Shiba, Ayako Kinoshita, Tadashi Matsumoto and Yuichi Hori
The influences of gender and aging on optic nerve head microcirculation in healthy adults
Scientific Reports, 9(1), 15636, doi:10.1038/s41598-019-52145-1, 2019.
Tatsuhiko Kobayashi, Tomoaki Shiba, Yuji Nishiwaki, Ayako Kinoshita, Tadashi Matsumoto and Yuichi Hori
Influence of age and gender on the pulse waveform in optic nerve head circulation in healthy men and women
Scientific Reports, 9(1), 17895, doi:10.1038/s41598-019-54470-x, 2019.
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto and Yuichi Hori
Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation
Scientific Reports, 9(1), 18849, doi:10.1038/s41598-019-55470-7, 2019.
Takashi Itokawa, Takashi Suzuki, Yukinobu Okajima, Tatsuhiko Kobayashi, Hiroko Iwashita, Satoshi Gotoda, Koji Kakisu, Yuto Tei and Yuichi Hori
Correlation between Blood Flow and Temperature of the Ocular Anterior Segment in Normal Subjects
Diagnostics, 10(9), 695, doi:10.3390/diagnostics10090695, 2020.
Kento Watanabe, Tomoaki Shiba, Tetsuya Komatsu, Kiyoshi Sakuma, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara and Yuichi Hori
The influence of hemorrhagic shock on ocular microcirculation by obtained by laser speckle flowgraphy in a white rabbit model
Microcirculation, e12716, doi:10.1111/micc.12716, 2021.
Shun Kumashiro, Seiji Takagi, Takashi Itokawa, Akiko Tajima, Tatsuhiko Kobayashi and Yuichi Hori
Decrease in choroidal blood flow after half and one-third dose verteporfin photodynamic therapy for chronic central serous chorioretinopathy
BMC Ophthalmology, 21(1), 1-8, doi:10.1186/s12886-021-01980-w, 2021.
Takashi Itokawa, Sayaka Sumazaki, Yukinobu Okajima, Koji Kakisu, Takashi Suzuki and Yuichi Hori
Changes in ocular anterior segment blood flow and temperature after thermal pulsation treatment in patients with meibomian gland dysfunction
Investigative Ophthalmology and Visual Science, 62(8), 1239, 2021 ARVO Annual Meeting abstract, 2021.
Tetsuya Komatsu, Tomoaki Shiba, Kento Watanabe, Kiyoshi Sakuma, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara and Yuichi Hori
Real-Time Evaluation of Regional Arterial Stiffening, Resistance, and Ocular Circulation During Systemic Administration of Adrenaline in White Rabbits
Translational Vision Science and Technology, 10(9), 11-11, doi:10.1167/tvst.10.9.11, 2021.
Tatsuhiko Kobayashi, Tomoaki Shiba, Kenji Okamoto, Tomohiko Usui and Yuichi Hori
Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-022-05631-8, 2022.
Takashi Itokawa, Yukinobu Okajima, Hiroko Iwashita, Koji Kakisu and Yuichi Hori
Effect of wind stimulation on ocular surface temperatures and blood flow in soft contact lens wearers
Investigative Ophthalmology and Visual Science, 63(7), 520-A0218, 2022 ARVO Annual Meeting abstract, 2022.
Takashi Itokawa, Yukinobu Okajima, Hiroko Iwashita, Kakisu Koji, Takashi Suzuki and Yuichi Hori
Association between mask-associated dry eye (MADE) and corneal sensations
Scientific Reports, 13(1), 1625, doi:10.1038/s41598-022-23994-0, 2023.
Takashi Itokawa, Tadashi Matsumoto, Saiko Matsumura, Momoko Kawakami and Yuichi Hori
Ocular blood flow evaluation by laser speckle flowgraphy in pediatric patients with anisometropia
Frontiers in Public Health, 11, 1093686, doi:10.3389/fpubh.2023.1093686, 2023.

Department of Ophthalmology, Toho University Ohashi Medical Center

Ayako Anraku, Kyoko Ishida, Nobuko Enomoto, Seiji Takagi, Hiroyuki Ito, Asuka Takeyama, Fumihiko Yagi and Goji Tomita
Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect
Journal of Ophthalmology, doi: 10.1155/2017/3608396, 2017.
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida and Goji Tomita
Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma
Journal of Ophthalmology, doi: 10.1155/2018/1751857, 2018.
Haruka Moroi, Ayako Anraku, Kyoko Ishida and Goji Tomita
Factors Related to a Right-Left Difference in Visual Field Defect in the Eyes with Untreated Normal Tension Glaucoma
Journal of Ophthalmology, doi: 10.1155/2018/4595214, 2018.
Satoko Masai, Kyoko Ishida, Ayako Anraku, Tetsuro Takumi and Goji Tomita
Pulse Waveform Analysis of the Ocular Blood Flow Using LaserSpeckle Flowgraphy before and after Glaucoma Treatment
Journal of Ophthalmology, doi: 10.1155/2019/1980493, 2019.
Ayako Anraku, Nobuko Enomoto, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta and Makoto Araie
Ocular and Systemic Factors Affecting Laser Speckle Flowgraphy Measurements in the Optic Nerve Head
Translational Vision Science & Technology, 10(1), 13, doi:10.1167/tvst.10.1.13, 2021.
Nobuko Enomoto, Ayako Anraku, Goji Tomita, Aiko Iwase, Takashi Sato, Nobuyuki Shoji, Tomoaki Shiba, Toru Nakazawa, Kazuhisa Sugiyama, Koji Nitta and Makoto Araie
Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation
Scientific Reports, 11(1), 1-12, doi:10.1038/s41598-021-86280-5, 2021.

Department of Neurosurgery, Toho University Ohashi Medical Center

Masashi Ishii, Morito Hayashi, Fumihiko Yagi, Kenichiro Sato, Goji Tomita and Satoshi Iwabuchi
Relationship between the Direction of Ophthalmic Artery Blood Flow and Ocular Microcirculation before and after Carotid Artery Stenting.
Journal of Ophthalmology, doi: 10.1155/2016/2530914, 2016.

Department of Ophthalmology, University of Tokyo

Yasuhiro Tamaki, Eizo Kawamoto, Shuichiro Eguchi, Makoto Araie and Hitoshi Fujii
An Application of laser speckle phenomenon for non-invasive 2-dimensional evaluation of microcirculation in ocular fundus
Jpn. J. Ophthalmol, 37, no.2, 178-186, 1993.
Y. Tamaki, M. Araie, E. Kawamoto, S. Eguchi and H. Fujii
Noncontact, Two-Dimensional Measurement of Retinal Microcirculation Using Laser Speckle Phenomenon Invest.
Ophthalmol. Vis. Sci., 35, no.11, 3825-3834, 1994.
Y. Tamaki, M. Araie, E. Kawamoto, S. Eguchi and H. Fujii
Noncontact, Two-Dimensional Measurement of Tissue Circulation in Choroid and Optic Nerve Head Using Laser Speckle Phenomenon
Exp. Eye Res., 60, 373-384, 1995.
Y.Tamaki and M. Araie
Time Change of Nicardipine Effect on Tissue Circulation in Retina in Living Rabbit eyes
Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995
Y. Tamaki, M. Araie, K. Tomita, M. Nagahara, A. Tomidokoro and H. Fujii
Real-Time Measurement of Human Optic Nerve Head and Choroid Circulation, Using the Laser Speckle Phenomenon
Jpn. J Ophthalmol., 41, 49-54, 1997.
Miyuki Nagahara, Yasuhiro Tamaki, Atsuo Tomidokoro and Makoto Araie
In Vivo Measurement of Blood Velocity in Human Major Retinal Vessels Using the Laser Speckle Method
Invest. Ophthalmol. Vis. Sci. August 11, 2010
Chihiro Mayama
Calcium channels and their blockers in intraocular pressure and glaucoma
European Journal of Pharmacology, Available online 1 December 2013.

Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University

Hidetaka Noma, Kanako Yasuda, Terumi Minezaki, Sho Watarai, and Masahiko Shimura
Changes of retinal flow volume after intravitreal injection of bevacizumab in branch retinal vein occlusion with macular edema: a case series
BMC ophthalmology, 16(1), 61, doi:10.1186/s12886-016-0239-8, 2016.
Hidetaka Noma, Kanako Yasuda, Tatsuya Mimura, Akemi Ofusa, and Masahiko Shimura
Relationship between retinal blood flow and cytokines in central retinal vein occlusion
BMC Ophthalmology, 20(1), 215, doi:10.1186/s12886-020-01486-x, 2020.
Toru Mizui, Hidetaka Noma, Kanako Yasuda, Tomoe Kanemaki, Hiroshi Goto and Masahiko Shimura
Intravitreal ranibizumab reduced ocular blood flow and aqueous cytokine levels and improved retinal morphology in patients with diabetic macular edema
Scientific Reports, 10(1), 1-8, doi:10.1038/s41598-020-78792-3, 2020.
Hidetaka Noma, Kanako Yasuda, Tatsuya Mimura, Noboru Suganuma and Masahiko Shimura
Retinal Microcirculation and Cytokines as Predictors for Recurrence of Macular Edema after Intravitreal Ranibizumab Injection in Branch Retinal Vein Occlusion
Journal of Clinical Medicine, 10(1), 58, doi:10.3390/jcm10010058, 2020.
Yurika Takano, Hidetaka Noma, Kanako Yasuda, Tomoe Yamaguchi, Hiroshi Goto and Masahiko Shimura
Retinal Blood Flow as a Predictor of Recurrence of Macular Edema after Intravitreal Ranibizumab Injection in Central Retinal Vein Occlusion
Ophthalmic Research, doi:10.1159/000519150, 2021.
Kanako Yasuda, Hidetaka Noma, Tatsuya Mimura, Ryota Nonaka, Shotaro Sasaki, Noboru Suganuma and Masahiko Shimura
Effects of Intravitreal Ranibizumab Injection on Peripheral Retinal Microcirculation and Cytokines in Branch Retinal Vein Occlusion with Macular Edema
Medicina, 59(6), 1053, doi:10.3390/medicina59061053, 2023.
Kanako Yasuda, Hidetaka Noma, Eri Oyama, Kosei Yanagida, Masaki Asakage and Masahiko Shimura
Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters
Ophthalmic Research, doi:10.1159/000531498, 2023.

Department of Ophthalmology, Tokyo Medical and Dental University

Ryoko Soma, Muka Moriyama and Kyoko Ohno-Matsui
Hemodynamics of focal choroidal excavations
International Ophthalmology, 1-8, 2015.

Division of Ophthalmology, Nihon University

Taiji Nagaoka, HIrotsugu Hanazaki, Hiroyuki Nakashizuka, Hajime Onoe, Hiroshi Aso, Junya Hanaguri, Masahisa Watanabe, Harumasa Yokota and Satoru Yamagami
Evaluation of ocular blood flow in response to induced systemic hyperoxia using a Laser Speckle Flowgraphy in anesthetized pigs
Investigative Ophthalmology & Visual Science, 61(7), 1742, 2020.
Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Lih Kuo, Satoru Yamagami and Taiji Nagaoka
Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy
Scientific Reports, 10(1), 1-9, doi:10.1038/s41598-020-75296-y, 2020.
Hirotsugu Hanazaki, Harumasa Yokota, Hiroshi Aso, Satoru Yamagami and Taiji Nagaoka
Evaluation of ocular blood flow over time in a treated retinal arterial macroaneurysm using laser speckle flowgraphy
American journal of ophthalmology case reports, 21, 101022, doi:10.1016/j.ajoc.2021.101022, 2021.
Harumasa Yokota, Taiji Nagaoka, Hidetaka Noma, Akemi Ofusa, Tomoe Kanemaki, Hiroshi Aso, Hirotsugu Hanazaki, Satoru Yamagami and Masahiko Shimura
Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment
Scientific Reports, 11(1), 1-8, doi:10.1038/s41598-021-94993-w, 2021.
Hanaguri J, Yokota H, Watanebe M, Yamagami S, Kushiyama A, Kuo L, Nagaoka T.
Retinal Blood Flow Dysregulation Precedes Neural Retinal Dysfunction in Type 2 Diabetic Mice.
Scientific Reports, 11(1), 1-11, doi:10.1038/s41598-021-97651-3, 2021.
Yasunari Ebuchi, daisuke fukamachi, Keisuke Kojima, Taiji Nagaoka, Nobuhiro Murata, Akihito Ohgaku, Yutaka Koyama, Hidesato Fujito, Riku Arai, Masaki Monden, Takehiro Tamaki, Daisuke Kitano, Yasuo Okumura, Satoru Yamagami
Comprehensive Assessment of Systemic Atherosclerosis in Relation to the Ocular Resistive Index in Acute Coronary Syndrome Patients.
Circulation, 144(Suppl_1), A8881-A8881, 2021.
Harumasa Yokota, Hiroki Hayashi, Junya Hanaguri, Satoru Yamagami, Akifumi Kushiyama, Hironori Nakagami and Taiji Nagaoka
Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes
PLOS ONE, 17(1), e0262568, doi:10.1371/journal.pone.0262568, 2022.
Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami and Taiji Nagaoka
The Effect of Sodium-Dependent Glucose Cotransporter 2 Inhibitor Tofogliflozin on Neurovascular Coupling in the Retina in Type 2 Diabetic Mice
International Journal of Molecular Sciences, 23(3), 1362, doi:10.3390/ijms23031362, 2022.
Junya Hanaguri, Noriaki Nagai, Harumasa Yokota, Akifumi Kushiyama, Masahisa Watanabe, Satoru Yamagami and Taiji Nagaoka
Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice
Pharmaceutics, 14(2), 384, doi:10.3390/pharmaceutics14020384, 2022.
Taiji Nagaoka, Yasunari Ebuchi, Akifumi Kushiyama, Daisuke Fukamachi, Harumasa Yokota, Satoru Yamagami and Yasuo Okumura
Relation between choroidal blood flow parameters and systemic atherosclerosis in patients with acute coronary syndrome
Investigative Ophthalmology and Visual Science, 64(8), 458, 2023 ARVO Annual Meeting abstract, 2023.
Ruri Sugiyama, Takako Ohnishi, Satoru Yamagami and Taiji Nagaoka
A case of acute syphilitic posterior placoid chorioretinitis showing improved choroidal blood flow after treatment
American Journal of Ophthalmology Case Reports, 32, 101880, doi:10.1016/j.ajoc.2023.101880, 2023.
Taiji Nagaoka, Harumasa Yokota, Masahisa Watanabe, Hiroshi Aso, Koyo Takase, Junya Hanaguri, Akira Ohno, Akifumi Kushiyama, Seiyo Harino and Satoru Yamagami
Impairment of flicker-induced increase in retinal blood flow in diabetic pigs
Japanese Journal of Ophthalmology, doi:10.1007/s10384-024-01073-3, 2024.
Yoshinari Saima, Harumasa Yokota, Akifumi Kushiyama, Junya Hanaguri, Akira Ohno, Koyo Takase, Ruri Sugiyama, Kimimasa Muranaka, Satoru Yamagami and Taiji Nagaoka
Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema
Scientific Reports, 14, doi:10.1038/s41598-024-63435-8, 2024.
Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, Tsutomu Igarashi, Masumi Iketani, Ikuroh Ohsawa, Seiyo Harino, Hiroyuki Nakashizuka, Satoru Yamagami and Taiji Nagaoka
Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice
Translational Vision Science and Technology, 13(10), 36, doi:10.1167/tvst.13.10.36, 2024.

Division of Cardiology, Nihon University

Yasunari Ebuchi, Taiji Nagaoka, Daisuke Fukamachi, Keisuke Kojima, Naotaka Akutsu, Nobuhiro Murata, Yuki Saito, Daisuke Kitano, Harumasa Yokota, Satoru Yamagami and Yasuo Okumura
Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients
Scientific Reports, 12(1), 1-11, doi:10.1038/s41598-021-04196-6, 2022.

Department of Ophthalmology, Kyorin University

Toshiki Watanabe, Yukihiko Mashima, Kazuteru Kigasawa, Asako Mashima, Masahiko Shimura and Akito Hirakata
Increased Microcirculation on Optic Nerve Head by Laser Speckle Flowgraphy at Early Stage of Leber Hereditary Optic Neuropathy
Neuro-Ophthalmology, 43(6), 411-416, doi:10.1080/01658107.2018.1526956, 2018.

Tokyo Institute of Technology

Tsukasa Ikemura, Akane Miyaji, Hideaki Kashima, Yuji Yamaguchi, Naoyuki Hayashi
Ocular blood flow decreases during passive heat stress in resting humans
Journal of Physiological Anthropology 2013, 32:23 doi:10.1186/1880-6805-32-23
Tsukasa Ikemura, Naoyuki Hayashi
Effects of Heat Stress on Ocular Blood Flow during Exhaustive Exercise
Journal of Sports Science and Medicine (2014) 13, 172-179
A. Miyaji, T. Ikemura, Y. Hamada and N. Hayashi
Regional differences in the vascular response to CO 2 among cerebral, ocular, and mesenteric vessels.
Artery Research, Available online 6 September 2015. doi:10.1016/j.artres.2015.08.001
A. Miyaji, T. Ikemura and N. Hayashi
Effect of Aging on the Blowout Time in Various Ocular Vessels
Aging Sci, 4(148), 2, 2016
Naoyuki Hayashi, Lanfei Du
Acute and Chronic Periocular Massage for Ocular Blood Flow and Vision: a Randomized Controlled Trial
International Journal of Therapeutic Massage & Bodywork, 14(2), 5-13, 2021.
Chihyun Liu, Tatsuhiko Kobayashi, Tomoaki Shiba and Naoyuki Hayashi
Effects of aging and exercise habits on blood flow profile of the ocular circulation
PLOS ONE, 17(4), e0266684, doi:10.1371/journal.pone.0266684, 2022.

Faculty of Sport Sciences, Waseda University

Tsukasa Ikemura, Hideaki Kashima, Yuji Yamaguchi, Akane Miyaji and Naoyuki Hayashi
Inner ocular blood flow responses to an acute decrease in blood pressure in resting humans
Physiological measurement, 36(2), 219.

Faculty of Commerce, Yokohama College of Commerce

Tsukasa Ikemura, Naoyuki Hayashi
Inner ocular blood flow response to exercise in healthy humans
The Journal of Physical Fitness and Sports Medicine, 6(4), 223-226, doi:10.7600/jpfsm.6.223, 2017.
Tsukasa Ikemura, Katsuhiko Suzuki, Nobuhiro Nakamura, Koichi Yada and Naoyuki Hayashi
Fluid intake restores retinal blood flow early after exhaustive exercise in healthy subjects
European Journal of Applied Physiology, doi:10.1007/s00421-018-3839-6, 2018.

College of Liberal Arts and Science, Kitasato University

Tsukasa Ikemura, Nobuhiro Nakamura, and Naoyuki Hayashi
Impact of acute dynamic exercise on vascular stiffness in the retinal arteriole in healthy subjects
Journal of Applied Physiology, 132(2). 459-468, doi:10.1152/japplphysiol.00507.2021, 2021.

Ophthalmology and Visual Science, Kanazawa University

Yasushi Wada, Tomomi Higashide, Atsushi Nagata and Kazuhisa Sugiyama
Longitudinal Changes in Optic Nerve Head Blood Flow in Normal Rats Evaluated by Laser Speckle Flowgraphy.
IOVS, 57(13), 5568-5575, 2016.
Yutaro Yamada, Tomomi Higashide, Sachiko Udagawa, Satoshi Takeshima, Kimikazu Sakaguchi, Koji Nitta and Kazuhisa Sugiyama
The Relationship Between Interocular Asymmetry of Visual Field Defects and Optic Nerve Head Blood Flow in Patients with Glaucoma
Journal of Glaucoma、doi:10.1097/IJG.0000000000001181, 2018.
Yasushi Wada, Tomomi Higashide, Atsushi Nagata and Kazuhisa Sugiyama
Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-018-4191-6, 2018.
Satoshi Takeshima, Tomomi Higashide, Masayo Kimura, Sachiko Udagawa, Yutaro Yamada, Daisuke Takemoto, Shinji Ohkubo and Kazuhisa Sugiyama
Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma
Investigative Ophthalmology & Visual Science, 60(2), 677-684, doi:10.1167/iovs.18-25694, 2019.
Yuki Takamatsu, Tomomi Higashide, Satoshi Takeshima, Makoto Sasaki, Yoshimi Manbo, Sachiko Udagawa, Shinji Ohkubo, Shozo Sonoda, Taiji Sakamoto and Kazuhisa Sugiyama
Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy
Translational Vision Science and Technology, 10(14), 30, doi:10.1167/tvst.10.14.30, 2021.
Yasushi Wada, Tomomi Higashide, Kimikazu Sakaguchi, Atsushi Nagata, Kazuyuki Hirooka and Kazuhisa Sugiyama
Compromised blood flow in the optic nerve head after systemic administration of 2 aldosterone in rats: A possible rat model of retinal ganglion cell loss
Current Eye Research, doi:10.1080/02713683.2022.2029907, 2022.
Makoto Sasaki, Tomomi Higashide, Satoshi Takeshima, Yuki Takamatsu, Yoshimi Manbo, Sachiko Udagawa and Kazuhisa Sugiyama
Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma
Scientific Reports, 12(1), 9802, doi:10.1038/s41598-022-13989-2, 2022.

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University

Shinichiro Fuma, Anri Nishinaka, Yuki Inoue, Kazuhiro Tsuruma, Masamitsu Shimazawa, Mineo Kondo and Hideaki Hara
A pharmacological approach in newly established retinal vein occlusion model
Scientific Reports, 7, doi:10.1038/srep43509, 2017.
Mayu Moriguchi, Shinsuke Nakamura, Yuki Inoue, Anri Nishinaka, Maho Nakamura, Masamitsu Shimazawa and Hideaki Hara
Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation
Investigative Ophthalmology & Visual Science, 59(8), 3476-3487, 2018.
Anri Nishinaka, Yuki Inoue, Shinichiro Fuma, Yoshifumi Hida, Shinsuke Nakamura, Masamitsu Shimazawa and Hideaki Hara
Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion
Investigative Ophthalmology & Visual Science, 59(11), 4701-4713, 2018.
Anri Nishinaka, Koki Nitta, Takashi Seki, Hideaki Hara and Masamitsu Shimazawa
The Changes in Blood Flow Seen in the Eye after Foot Acupuncture Treatment in Mice
Evidence-Based Complementary and Alternative Medicine, 2020, 6405471, doi: 10.1155/2020/6405471, 2020.
Shinsuke Nakamura, Anri Nishinaka, Yae Hidaka, Masamitsu Shimazawa, Leo Thomas, Remko A. Bakker and Hideaki Hara
Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model
Investigative Ophthalmology and Visual Science, 63(8), 14, doi: 10.1167/iovs.63.8.14, 2022.
Anri Nishinaka, Miruto Tanaka, Kentaro Ohara, Eiji Sugaru, Yuji Shishido, Akemi Sugiura, Yukiko Moriguchi, Amane Toui, Shinsuke Nakamura, Kaoru Shimada, Shuzo Watanabe, Hideaki Hara and Masamitsu Shimazawa
TRPV4 channels promote vascular permeability in retinal vascular disease
Experimental Eye Research, 228, 109405, doi: 10.1016/j.exer.2023.109405, 2023.

Department of Ophthalmology, Nagoya University

Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Kenta Murotani, Shigeyuki Matsui, and Hiroko Terasaki
Diurnal Variations in Blood Flow at Optic Nerve Head and Choroid in Healthy Eyes: Diurnal Variations in Blood Flow.
Medicine, 94(6): e819, 2015.
Kosei Yanagida, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Hiroki Kaneko, Kenta Murotani, Shigeyuki Matsui and Hiroko Terasaki
Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy.
IOVS, 56(8), 4880-4890, 2015. doi:10.1167/iovs.15-16567
Takeshi Iwase, Eimei Ra, Kentaro Yamamoto, Hiroki Kaneko, Yasuki Ito and Hiroko Terasaki
Differences of Retinal Blood Flow Between Arteries and Veins Determined by Laser Speckle Flowgraphy in Healthy Subjects
Medicine, 94(33): e1256, 2015.
Takeshi Iwase, Kentaro Yamamoto, Misato Kobayashi, Eimei Ra, Kenta Murotani and Hiroko Terasaki
What ocular and systemic variables affect choroidal circulation in healthy eyes
Medicine, 95(43): e5102, 2016.
Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra and Hiroko Terasaki
Changes in Blood Flow on Optic Nerve Head After Vitrectomy for Rhegmatogenous Retinal Detachment
IOVS, 57(14), 6223-6233, 2016. doi:10.1167/iovs.16-20577
Marie Fukami, Takeshi Iwase, Kentaro Yamamoto, Hiroki Kaneko, Shunsuke Yasuda and Hiroko Terasaki
Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion
IOVS, 58(2), 1246-1255, 2017. doi:10.1167/iovs.16-21115
Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
Effects of photocoagulation on ocular blood flow in patients with severe non-proliferative diabetic retinopathy
PLOS ONE, 12(3), e0174427, doi:10.1371/journal.pone.0174427, 2017.
Marie Fukami, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Kenta Murotani and Hiroko Terasaki
Diurnal variation of pulse waveform parameters determined by laser speckle flowgraphy on the optic nerve head in healthy subjects.
Medicine, 96(44): e8312, 2017.
Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra and Hiroko Terasaki
Change in choroidal blood flow and choroidal morphology due to segmental scleral buckling in eyes with rhegmatogenous retinal detachment
Scientific Reports, 7(1), 5997, doi:10.1038/s41598-017-05126-1, 2017.
Takeshi Iwase, Kentaro Yamamoto, Kosei Yanagida, Eimei Ra, Yasuki Ito, Kenta Murotani and Hiroko Terasaki
Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy
Scientific Reports, 7(1), 13878, doi:10.1038/s41598-017-14118-0, 2017.
Yuji Mikoshiba, Takeshi Iwase, Yoshitaka Ueno, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation
Scientific Reports, 8(1), 14128, doi:10.1038/s41598-018-32487-y, 2018.
Takeshi Iwase, Tomohiko Akahori, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
Evaluation of optic nerve head blood flow in response to increase of intraocular pressure
Scientific Reports, 8(1), 17235, doi:10.1038/s41598-018-35683-y, 2018.
Fumi Kuroda, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
Correlation between blood flow on optic nerve head and structural and functional changes in eyes with glaucoma
Scientific Reports, 10, 729, doi:10.1038/s41598-020-57583-w, 2020.
Ryo Tomita, Takeshi Iwase, Yoshitaka Ueno, Kensuke Goto, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki
Differences in Blood Flow Between Superior and Inferior Retinal Hemispheres
Investigative Ophthalmology and Visual Science, 61(5), 27, doi:10.1167/iovs.61.5.27, 2020.
Yoshitaka Ueno, Takeshi Iwase, Kensuke Goto, Ryo Tomita, Eimei Ra, Kentaro Yamamoto and Hiroko Terasaki
Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy
Scientific Reports, 11(1), 1-12, doi:10.1038/s41598-021-84067-2, 2021.
Chie Iwase, Takeshi Iwase, Ryo Tomita, Tomohiko Akahori, Eimei Ra, Kentaro Yamamoto and Hiroko Terasaki
Changes in pulse waveforms in response to intraocular pressure elevation determined by laser speckle flowgraphy in healthy subjects
BMC Ophthalmology, 21(1), 1-13, doi:10.1186/s12886-021-02070-7, 2021.
Ryo Tomita, Takeshi Iwase, Marie Fukami, Kensuke Goto, Eimei Ra and Hiroko Terasaki
Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
Scientific Reports, 11(1), 1-11, 10.1038/s41598-021-99572-7, 2021.
Etsuyo Horiguchi, Jun Takeuchi, Ryo Tomita, Keiko Asai, Yuyako Nakano, Hikaru Ota, Yosuke Taki, Yasuki Ito, Hiroko Terasaki, Koji M Nishiguchi and Keiko Kataoka
Choroidal Hemodynamics in Central Serous Chorioretinopathy after Half-dose Photodynamic Therapy and the Effects of Smoking
Scientific Reports, doi:10.21203/rs.3.rs-1776430/v1, 2022.
Ryo Tomita, Takeshi Iwase
Visualization of Changes in Retinal Vascular Resistance Before and After Administration of Anti-Vascular Endothelial Growth Factor for Branch Retinal Vein Occlusion
Ophthalmic Surgery, Lasers and Imaging Retina, doi:10.3928/23258160-20230809-01, 2023.

Department of Ophthalmology, Osaka Medical and Pharmaceutical University

S.Kojima, T. Sugiyama, M. Toda, H. Oku, K. Shimizu, O. Ishida, M. Nakajima and I. Azuma
Effect of nitric oxide on rabbit optic nerve head circulation
Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995.
Okuno T, Sugiyama T, Ikeda T
Correlation between Heidelberg Retina Flowmeter HRF and laser speckle flowgrafy LSFG
Invest Ophthalmol Vis Sci 2001;42:S84.
Okuno T, Sugiyama T, Kohyama M, Kojima S, Oku H, Ikeda T
Ocularblood flow changes after dynamic exercise in humans
Eye. 2006 Jul;20(7):796-800. Epub 2005 Jul 8.
Sugiyama T, Oku H, Komori A, et al
Effect of P2X7 receptor activation on the retinal blood velocity of diabetic rabbits
Arch Ophthalmol 124:1143-1149,2006
Sugiyama T, Kojima S, Ishida O, Ikeda T
Changes in optic nerve head blood flow induced by the combined therapy of latanoprost and beta blockers.
Acta Ophthalmol 2008 Dec 2.
Sugiyama T, Mashima Y, Yoshioka Y, Oku H, Ikeda T
Effect of unoprostone on topographic and blood flow changes in the ischemic optic nerve head of rabbits.
Arch Ophthalmol 127(4):454-9,2009
Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S
Use of laser speckle flowgraphy in ocular blood flow research.
Acta Ophthalmol. :2009 Sep 2.
Tetsuya Sugiyama, Maho Shibata, Sumiko Kajiura, Takashi Okuno, Masahiro Tonari, Hidehiro Oku and Tsunehiko Ikeda
Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.
Investigative ophthalmology & visual science, 52(1): 64-69, 2011.
Shibata M, Oku H, Sugiyama T, Kobayashi T, Tsujimoto M, Okuno T, Ikeda T.
Disruption of Gap Junctions May Be Involved in Impairment of Autoregulation in Optic Nerve Head Blood Flow of Diabetic Rabbits
IOVS 2011; 52: 2152-2159.
Maho Shibata, Tetsuya Sugiyama, Masaaki Hoshiga, Junko Hotchi, Takashi Okuno, Hidehiro Oku, Toshiaki Hanafusa and Tsunehiko Ikeda
Changes in optic nerve head blood flow, visual function, and retinal histology in hypercholesterolemic rabbits
Experimental Eye Research, 93(6), 818-824, 2011.
Maho Shibata, Tetsuya Sugiyama, Takuji Kurimoto,Hidehiro Oku, Takashi Okuno, Takatoshi Kobayashi ,Tsunehiko Ikeda
Involvement of Glial Cells in the Autoregulation of Optic Nerve Head Blood Flow in Rabbits
IOVS 2012; 53: doi: 10.1167/iovs.11-9316
Ryohsuke Kohmoto, Tetsuya Sugiyama, Shota Kojima, Mari Ueki and Tsunehiko Ikeda
Optic Nerve Head Blood Flow Changes Induced by Ripasudil Added to Prostaglandin Analogues in Primary Open Angle Glaucoma
EC Ophthalmology, 4(6), 640-647, 2017.
Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie and Tsunehiko Ikeda
Vasoactivity of retinal veins: A potential involvement of endothelin-1 (ET-1) in the pathogenesis of retinal vein occlusion (RVO).
Experimental Eye Research, doi:10.1016/j.exer.2018.07.016, 2018.
Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie and Tsunehiko Ikeda
Vasoactivity of retinal veins
Data in Brief, doi:10.1016/j.dib.2018.09.070, 2018.
Mari Ueki, Tetsuya Sugiyama, Ryohsuke Kohmoto, Shota Kojima, Michiko Maeda, Emika Nemoto, Satoru Tokuoka and Tsunehiko Ikeda
Blood Flow in the Optic Nerve Head Changes after Disc Hemorrhage in Primary Open Angle Glaucoma
EC Ophthalmology, 10(3), 230-235, 2019.
Ryohsuke Kohmoto, Tetsuya Sugiyama, Mari Ueki, Shota Kojima, Michiko Maeda, Emika Nemoto, Satoru Tokuoka and Tsunehiko Ikeda
Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes
Clinical Ophthalmology, 13, 1799-1805, 2019.
Masashi Mimura, Yuko Nishikawa, Keiko Inagaki, Yohei Sato, Yasushi Fujita and Don O Kikkawa
Change of intraocular blood flow during treatment for thyroid eye disease
Taiwan Journal of Ophthalmology, 12(1), 97, doi:10.4103/tjo.tjo_2_22, 2022.

Nakano Eye Clinic

Tetsuya Sugiyama
Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases
Photonics, 1, no.3, 220-234, 2014. doi:10.3390/photonics1030220
Tetsuya Sugiyama, Hajime Nakamura, Emiko Shimizu, Kazuaki Miyamoto and Ryozo Yamada
Clinical Usefulness of the Measurement of Optic Nerve Head Blood Flow in Myopic Normal-Tension Glaucoma
International Journal of Ophthalmic Research 2015 June 1(1): 11-18
Tetsuya Sugiyama
Coexisting Normal-Tension Glaucoma and Deficiencies of Folic Acid and Vitamin B6 (Pyridoxal)
International Journal of Ophthalmology and Clinical Research, 2(4):037, 2015.
Tetsuya Sugiyama and Hajime Nakamura
Increased Short-Term Fluctuation in Optic Nerve Head Blood Flow in a Case of Normal-Tension Glaucoma by the Use of Laser Speckle Flowgraphy.
Vision 2016, 1, 5.
Tetsuya Sugiyama, Emiko Shimizu and Kazuaki Miyamoto
Ocular Blood Flow Changes in a Case with Nonarteritic Ischemic Optic Neuropathy Complicated by Obstructive Sleep Apnea Syndrome
EC Ophthalmology, 9.6, 361-367, 2018.

Tane Memorial Eye Hospital

T.Maeno, R.Tano, M.Sakamoto, N.Onishi, K.Kakurai, T.Yamada, H.Fujii, T.Mano
Measurement of Retinal Blood Flow Volume by Laser Speckle Flowgraphy Before and After Arteriovenous Sheathotomy for Branch Retinal Vein Occlusion
ARVO, 2008, (4265/A358)
R.Tano, M.Sakamoto, M.Ikeda, S.Sugita, H.Fujii, T.Mano, T.Maeno
Analysis of Retinal Blood Flow by Laser Speckle Flowgraphy in a Case With Central Retinal Vein Occlusion After Radial Optic Neurotomy
ARVO, 2008, (4274/A367)

National Cerebral and Cardiovascular Center

Junichi Shimamura, Tomohiro Nishinaka, Toshihide Mizuno, Tomonori Tsukiya, Ayako Inatomi, Futoshi Kobayashi, Nobumasa Katagiri, Yoshiaki Takewa, Takashi Nishimura and Eisuke Tatsumi
Assessment of ocular blood flow in continuous-flow ventricular assist device by laser speckle flowgraphy
Journal of Artificial Organs, 1-6, doi:10.1007/s10047-021-01265-5, 2021.

Department of Ophthalmology, Kyoto University

Yoshimasa Kuroda, Akihito Uji and Nagahisa Yoshimura
Factors associated with optic nerve head blood flow and color tone: a retrospective observational study.
Graefe's Archive for Clinical and Experimental Ophthalmology, 1-8, 2016.

Department of Ophthalmology, Saneikai Tsukazaki Hospital

Daisuke Nagasato, Yoshinori Mitamura, Kentaro Semba, Kei Akaiwa, Toshihiko Nagasawa, Yuki Yoshizumi, Hitoshi Tabuchi and Yoshiaki Kiuchi
Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion: prospective, interventional case series
BMC ophthalmology, 16(1), doi:10.1186/s12886-016-0211-7, 2016.
Daisuke Nagasato, Yoshinori Mitamura, Mariko Egawa, Masahiro Kameoka, Toshihiko Nagasawa, Hitoshi Tabuchi, Takamasa Kinoshita, Shozo Sonoda and Taiji Sakamoto
Changes of choroidal structure and circulation after water drinking test in normal eyes
Graefe's Archive for Clinical and Experimental Ophthalmology, doi:10.1007/s00417-019-04427-7, 2019.
Daisuke Nagasato, Yoshinori Mitamura, Mariko Egawa, Fumiko Murao, Toshihiko Nagasawa, Natsumi Komori, Shozo Sonoda, Taiji Sakamoto and Hitoshi Tabuchi
Changes in Choroidal Component Ratio and Circulation After Coffee Intake in Healthy Subjects.
Investigative Ophthalmology & Visual Science, 62(3), 27-27, doi:10.1167/iovs.62.3.27, 2021.

Department of Ophthalmology, Nara Medical University

Okamoto M, Matsuura T, Ogata N
Ocular blood flow before, during, and after vitrectomy determined by laser speckle flowgraphy.
Ophthalmic Surg Lasers Imaging Retina. 2014 Mar 1;45(2):118-24. doi: 10.3928/23258160-20140306-04.
Masahiro Okamoto, Toyoaki Matsuura and Nahoko Ogata
EFFECTS OF PANRETINAL PHOTOCOAGULATION ON CHOROIDAL THICKNESS AND CHOROIDAL BLOOD FLOW IN PATIENTS WITH SEVERE NONPROLIFERATIVE DIABETIC RETINOPATHY.
RETINA, 36(4), 805-811, 2016.
Masahiro Okamoto, Mariko Yamashita and Nahoko Ogata
Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema
Graefe's Archive for Clinical and Experimental Ophthalmology, 1-8, doi: 10.1007/s00417-018-3939-3, 2018.

Department of Anesthesiology, Nara Medical University

Hironobu Hayashi, Masahiro Okamoto, Hideaki Kawanishi, Toyoaki Matsuura, Nobuoki Tabayashi, Shigeki Taniguchi and Masahiko Kawaguchi
Ocular blood flow measured by laser speckle flowgraphy during aortic arch surgery with antegrade selective cerebral perfusion.
Journal of Cardiothoracic and Vascular Anesthesia, 2016.
Hironobu Hayashi, Masahiro Okamoto, Hideaki Kawanishi, Nobuoki Tabayashi, Toyoaki Matsuura, Shigeki Taniguchi and Masahiko Kawaguchi
Association between optic nerve head blood flow measured by laser speckle flowgraphy and radial arterial pressure during aortic arch surgery.
Journal of Cardiothoracic and Vascular Anesthesia, 2017.
Ayako Oi, Hironobu Hayashi, Yasushi Motoyama, Hideaki Kawanishi, Ichiro Nakagawa, Hiroyuki Nakase and Masahiko Kawaguchi
Application of laser speckle flowgraphy to evaluate cerebral perfusion after carotid endarterectomy
Heliyon, 9(3), e14400, doi:10.1016/j.heliyon.2023.e14400, 2023.

Department of Neurosurgery, Nara Medical University

Yasushi Motoyama, Hironobu Hayashi, Hideaki Kawanishi, Kohsuke Tsubaki, Tsunenori Takatani, Yoshiaki Takamura, Masashi Kotsugi, Taekyun Kim, Shuichi Yamada, Ichiro Nakagawa, Young-Su Park, Masahiko Kawaguchi and Hiroyuki Nakase
Ocular blood flow by laser speckle flowgraphy to detect cerebral ischemia during carotid endarterectomy
Journal of Clinical Monitoring and Computing, doi: 10.1007/s10877-020-00475-1, 2020.

Department of Ophthalmology, Hiroshima University

Kazuyuki Hirooka, Kenji Oki, Keiko Ogawa-Ochiai, Yuta Nakaniida, Hiromitsu Onoe and Yoshiaki Kiuchi
Blood flow in the optic nerve head in patients with primary aldosteronism
PLOS ONE, 18(4), e0285039, doi:10.1371/journal.pone.0285039, 2023.

Department of Ophthalmology, Tokushima University

Takamasa Kinoshita , Junya Mori, Natsuki Okuda, Hiroko Imaizumi, Masanori Iwasaki, Miho Shimizu, Hirotomo Miyamoto, Kei Akaiwa, Kentaro Semba, Shozo Sonoda, Taiji Sakamoto and Yoshinori Mitamura
Effects of Exercise on the Structure and Circulation of Choroid in Normal Eyes.
PLOS ONE, 11(12), e0168336, 2016.

Department of Ophthalmology, Kagawa University

Yuki Nakano, Yukiko Myoshi, Yuta Koyama, Rie Osaka and Kiyoshi Suzuma
Retinal oxygen saturation and retinal vascular resistance before and after treatment for central retinal vein occlusion (CRVO)
Investigative Ophthalmology and Visual Science, 64(8), 1774, 2023 ARVO Annual Meeting abstract, 2023.
Yuta Koyama, Yukiko Myoshi, Rie Osaka, Yuki Nakano, Ayaka Hara and Kiyoshi Suzuma
Comparison of retinal blood flow and vascular resistance between diabetic macular edema and normal eyes
Investigative Ophthalmology and Visual Science, 64(8), 2638, 2023 ARVO Annual Meeting abstract, 2023.
Takeru Shimazaki, Eri Nitta, Nobuko Kobayashi, Hirokazu Kojima and Kiyoshi Suzuma
Effects of trabeculectomy on blood flow and waveform changes of laser speckle flowgraphy in open angle glaucoma
Investigative Ophthalmology and Visual Science, 64(8), 4716, 2023 ARVO Annual Meeting abstract, 2023.

Department of Ophthalmology, Kyushu University

Hiroshi Enaida, Kenji Okamoto, Hitoshi Fujii and Tatsuro Ishibashi
LSFG Findings of Proliferative Diabetic Retinopathy After Intravitreal Injection of Bevacizumab
Ophthalmic Surgery, Lasers and Imaging 41 Online(): e1-e3, 2010.
Masato Akiyama, Yasuhiro Ikeda, Noriko Yoshida, Shoji Notomi, Yusuke Murakami, Toshio Hisatomi, Hiroshi Enaida, Tatsuro Ishibashi
Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa
Acta Ophthalmologica, DOI: 10.1111/aos.12293, 2013.
Yusuke Murakami, Yasuhiro Ikeda, Masato Akiyama, Kota Fujiwara, Noriko Yoshida, Shunji Nakatake, Shoji Notomi, Takahiro Nabeshima, Toshio Hisatomi, Hiroshi Enaida and Tatsuro Ishibashi
Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa.
Acta Ophthalmologica, DOI: 10.1111/aos.12693, 2015.
Yusuke Murakami, Jun Funatsu, Shunji Nakatake, Kohta Fujiwara, Takashi Tachibana, Yoshito Koyanagi, Toshio Hisatomi, Shigeo Yoshida, Shozo Sonoda, Taiji Sakamoto, Koh-Hei Sonoda and Yasuhiro Ikeda
Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa
Investigative Ophthalmology & Visual Science, 59(2), 1134-1143, 2018.

Institute of Health Science, Kyushu University

Hayashi N, Ikemura T, Someya N
Effects of dynamic exercise and its intensity on ocular blood flow in humans.
Eur J Appl Physiol. 2011
Ikemura T, Someya N, Hayashi N
Autoregulation in the ocular and cerebral arteries during the cold pressor test and handgrip exercise.
Eur J Appl Physiol. 2011
Hideaki Kashima, Naoyuki Hayashi
Basic Taste Stimuli Elicit Unique Responses in Facial Skin Blood Flow
PLOS ONE 6(12) 2011: e28236. doi:10.1371/journal.pone.0028236
Naoyuki Hayashi, Tsukasa Ikemura, Nami Someya
Changes in ocular flow induced by hypo- and hypercapnia relate to static visual acuity in humans
Eye Reports 2011, volume.1:e8, Page.20-24
Tsukasa Ikemura, Naoyuki Hayashi
Ocular circulatory responses to exhaustive exercise in humans
Eur J Appl Physiol. 2012

Department of Ophthalmology, University of Occupational and Environmental Health

K.Nagaya, H. Takahashi, H. Fujii
Optic nerve head microcirculation using laser speckle flowgraphy in patients with normal tension glaucoma
ARVO, 1999, #1457/B365

Yamana Eye Hospital

Y.Yamana, M. Matsuo, N. Konishi and H. Fujii
Heidelberg Retina Flowmeter and Laser Speckle Flowgraphy System: a comparative evaluation
Microcirculation Annual, 13, 195-196, 1997.
Y.Yamana, M. Matsuo, N. Konishi and H. Fujii
Peripapillary tissue, retinal vessels and optic nerve head blood flow rates using laser speckle flowgraphy
20th European Conference on Microcirculation, 219-223, 1998.
Y.Yamana, M. Matsuo, K. Goya, N. Konishi and H. Fujii
Retinal Vessels and Peripapillary Tissue Blood Flow in Diabetes Using Laser Speckle Flowgraphy System: a comparative evaluation
Microcirculation Annual, 15,117-118, 1999.
Y.Yamana, M. Matsuo, Y. Koketu, K. Goya, M. Wakisaka, M. Iwase, M.Yoshinari, N. Konishi, H. Fujii
Effect Acute Hyperglycemia on Chorio-Retinal Blood Flow in IGT and Diabetes Mellitus
Microcirculation Annual, 18, 85-86, 2002
Y.Yamana, M. Matsuo, Y. Koketsu, K. Goya, M. Yoshinari, N. Konishi, H.Fujii
Dysregulation of the Postprandial Retinal Blood Flpw in Type 2 Diabetes
European Society for Microcirculation, 18,95-98, 2002

Department of Orthoptics, Fukuoka International University of Health and Welfare

Mayumi Haneda, Yuki Hashimoto, Airi Mishima, Daichi Saito and Takeshi Yoshitomi
Changes in choroidal circulation hemodynamics during the menstrual cycle in young, healthy women
PLOS ONE, 17(6), e0270501, doi:10.1371/journal.pone.0270501, 2022.
Sakurako Imabayashi, Yuki Hashimoto, Yumi Ishimaru, Rino Umemoto, Miho Chiyozono, Toshitaka Yamanokuchi and Takeshi Yoshitomi
Changes in Choroidal Circulation Hemodynamics Measured Using Laser Speckle Flowgraphy after a Cold Pressor Test in Young Healthy Participants
Tomography, 9(2), 790-797, doi:10.3390/tomography9020064, 2023.

Department of Ophthalmology, Kurume University School of Medicine

Nobuhiro Kato, Masatoshi Haruta, Kei Furushima, Rikki Arai, Yu Matsuo and Shigeo Yoshida
Decrease in Ocular Blood Flow Thirty Minutes After Intravitreal Injections of Brolucizumab and Aflibercept for Neovascular Age-Related Macular Degeneration
Clinical Ophthalmology, 2023(17), 1187-1192, doi:10.2147/OPTH.S407249, 2023.

Department of Ophthalmology, Saga University

Hiroshi Enaida, Shinji Nagata, Atsunobu Takeda, Shintaro Nakao, Yasuhiro Ikeda and Tatsuro Ishibashi
Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy
Japanese Journal of Ophthalmology, 1-7, doi:10.1007/s10384-016-0472-y, 2016.
Hiroaki Sakai, Kosuke Kawata, Jun Masuoka, Tomohisa Nishimura and Hiroshi Enaida
Diagnosis and clinical course of ocular ischemic syndrome with retinal vascular abnormalities due to unilateral ocular artery and internal carotid artery stenosis in a child with neurofibromatosis type 1: a case report
BMC Ophthalmology, 20(1), 426, doi:10.1186/s12886-020-01670-z, 2020.

Department of Ophthalmology, Nagasaki University

Matsumoto Makiko, Suzuma Kiyoshi, Fukazawa Yoshiko, Yamada Yoshihisa, Tsuiki Eiko, Fujikawa Azusa and Kitaoka Takashi
Retinal blood flow levels measured by Laser Speckle Flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.
Retinal Cases and Brief Reports, 8(1), 60-66, 2014.
Y.Yamada, K.Suzuma, M.Matsumoto, E.Tsuiki, A.Fujikawa, T.Harada and T.Kitaoka
Retinal Blood Flow Correlates to Aqueous Vascular Endothelial Growth Factor in Central Retinal Vein Occlusion.
RETINA, 35(10), 2037-2042, 2015.
Makiko Matsumoto, Kiyoshi Suzuma, Yoshihisa Yamada, Eiko Tsuiki, Azusa Fujikawa and Takashi Kitaoka
Retinal blood flow after intravitreal bevacizumab is a predictive factor for outcomes of macular edema associated with central retinal vein occlusion.
Retina, doi:10.1097/IAE.0000000000001531, 2017.
Makiko Matsumoto, Kiyoshi Suzuma, Fumito Akiyama, Kanako Yamada, Shiori Harada, Eiko Tsuiki and Takashi Kitaoka
Retinal Microvascular Resistance Estimated from Waveform Analysis Is Significantly Higher With a Threshold Value in Central Retinal Vein Occlusion
Translational Vision Science and Technology, 9(11), 4, doi:10.1167/tvst.9.11.4, 2020.
Makiko Matsumoto, Kiyoshi Suzuma, Fumito Akiyama, Kanako Yamada, Shiori Harada, Eiko Tsuiki and Takashi Kitaoka
Retinal Vascular Resistance Significantly Correlates With Visual Acuity After 1 Year of Anti-VEGF Therapy in Central Retinal Vein Occlusion
Translational Vision Science and Technology, 10(11), 19, doi:10.1167/tvst.10.11.19, 2021.

Department of Ophthalmology, University of Miyazaki

Tomoyuki Maekubo, Hideki Chuman, Nobuhisa Nao-i
Laser speckle flowgraphy for differentiating between nonarteritic ischemic optic neuropathy and anterior optic neuritis
Jpn. J. Ophthalmol., May 2013, (doi:10.1007/s10384-013-0246-8)
Takako Hidaka, Hideki Chuman and Nobuhisa Nao-I
Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy
Graefe's Archive for Clinical and Experimental Ophthalmology, 255(10), 1973-1980, 2017.
Hideki Chuman, Takako Sugimoto and Nobuhisa Nao-I
Vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries in vitro and increased optic disc blood flow in vivo.
Graefe's Archive for Clinical and Experimental Ophthalmology, 255(12), 2381-2388, 2017.

Devers Eye Institute, Legacy Health

Y.Liang, L. Wang, G. Cull, H. Fujii, J.C. Downs.
Systemic Blood Pressure Determines the Magnitude of IOP-Induced Blood Flow Change in the Optic Nerve Head of Non-Human Primate
ARVO, 2008, (3265)
Yi Liang, J. Crawford Downs, Brad Fortune, Grant Cull, George A. Cioffi, Lin Wang
Impact of Systemic Blood Pressure on the Relationship between Intraocular Pressure and Blood Flow in the Optic Nerve Head of Nonhuman Primates
IOVS, 50:2154-2160, May 2009
Yi Liang, Brad Fortune, Grant Cull, George A. Cioffi, Lin Wang
Quantification of dynamic blood flow autoregulation in Optic nerve head of rhesus monkeys
Experimental Eye Research, 90, no.2: 203-209, 2010.
Lin Wang, Grant A. Cull, Chelsea Piper, Claude F. Burgoyne, Brad Fortune
Anterior and Posterior Optic Nerve Head Blood Flow in Nonhuman Primate Experimental Glaucoma Model Measured by Laser Speckle Imaging Technique and Microsphere Method
IOVS, November 20, 2012 IOVS-12-10911
Chelsea Piper, Brad Fortune, Grant Cull, George A. Cioffi and Lin Wang
BASAL BLOOD FLOW AND AUTOREGULATION CHANGES IN THE OPTIC NERVE OF RHESUS MONKEYS WITH IDIOPATHIC BILATERAL OPTIC ATROPHY
IOVS, January 3, 2013 IOVS-12-9773
Grant Cull, Claude F. Burgoyne, Brad Fortune and Lin Wang
Longitudinal Hemodynamic Changes within the Optic Nerve Head in Experimental Glaucoma
IOVS, June 4, 2013 IOVS-13-12013
Lin Wang, Claude F. Burgoyne, Grant Cull, Simmon Thompson and Brad Fortune
Static Blood flow Autoregulation in the Optic Nerve Head in Normal and Experimental Glaucoma
IOVS, January 16, 2014 IOVS-13-13716
Jintao Yu, Yi Liang, Simon Thompson, Grant Cull, Lin Wang
Parametric transfer function analysis and modeling of blood flow autoregulation in the optic nerve head
Int J Physiol Pathophysiol Pharmacol 2014;6(1):13-22
Lin Wang, Grant Cull, Claude F. Burgoyne, Simon Thompson and Brad Fortune
Longitudinal Alterations in the Dynamic Autoregulation of Optic Nerve Head Blood Flow Revealed in Experimental Glaucoma
IOVS, May 8, 2014 IOVS-14-14020. doi:10.1167/iovs.14-14020
Lin Wang, Grant A. Cull and Brad Fortune
Optic Nerve Head Blood Flow Response to Reduced Ocular Perfusion Pressure by Alteration of Either the Blood Pressure or Intraocular Pressure
Current Eye Research, Posted online on June 9, 2014. (doi:10.3109/02713683.2014.924146)
Grant Cull, Reinhard Told, Claude F. Burgoyne, Simon Thompson, Brad Fortune and Lin Wang
Compromised Optic Nerve Blood Flow and Autoregulation Secondary to Neural DegenerationHemodynamics Secondary to Optic Nerve Degeneration.
IOVS, 56(12), 7286-7292, 2015.
Stuart K. Gardiner, Grant Cull, Brad Fortune and Lin Wang
Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma
IOVS, 60(8), 3110-3118, doi:10.1167/iovs.19-27389, 2019.
Stuart Keith Gardiner, Grant Cull, Juan Reynaud, Steven L Mansberger, Brad Fortune and Lin Wang
The relation between blood flow within the remaining peripapillary vasculature and functional progression in glaucoma
Investigative Ophthalmology & Visual Science, 61(7), 620, 2020.
Grant Cull, Crystal Jadach, Juan Reynaud, Kristine Ly, Michaela Dunn, Dawn Jennings, Trinity Holthausen, Howard Lockwood, Stuart Keith Gardiner, Lin Wang, Jennifer Wilk and Brad Fortune
Pharmacodynamic response of optic nerve head (ONH) tissue blood flow measured by laser speckle flowgraphy (LSFG) after administration of PER-001, an endothelin receptor antagonist
Investigative Ophthalmology and Visual Science, 63(7), 4029-A0414, 2022 ARVO Annual Meeting abstract, 2022.
Stuart K. Gardiner, Grant Cull, Brad Fortune
Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects
Investigative Ophthalmology and Visual Science, 64(7), 30, doi:10.1167/iovs.64.7.30, 2023.
Stuart Keith Gardiner, Cindy Albert, Brad Fortune, Steven L Mansberger and Grant Cull
Retinal vessel pulsatile characteristics can predict functional progression in glaucoma suspects
Investigative Ophthalmology and Visual Science, 64(8), 3778, 2023 ARVO Annual Meeting abstract, 2023.
Michaela Dunn, Grant Cull, Juan Reynaud, Dawn Jennings, Trinity Holthausen, Adriana Di Polo and Brad Fortune
Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage
Translational Vision Science and Technology, 12(8), 16, doi:10.1167/tvst.12.8.16, 2023.

Department of Veterinary Medicine and Surgery, University of Missouri

Shyam S. Chaurasia, Rayne R. Lim, Bhav H. Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D. Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R. Mohan and Veluchamy A. Barathi
The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy
Scientific reports, 8(1), 2847, doi:10.1038/s41598-018-21198-z, 2018.

Department of Ophthalmology and Visual Sciences, University of Iowa

Sophia M Chung, Zaidoon Al-Share, Matthew J. Thurtell, Ryuya Hashimoto and Randy Kardon
Blood Flow in the Optic Nerve and Peripapillary Choroid Correlate Over Time in NAION
Investigative Ophthalmology & Visual Science, 61(7), 804, 2020.
Ryuya Hashimoto, Zaidoon Al-Share, Nitsan Duvdevan-Strier, Jan M Full, Julie Nellis and Randy Kardon
Autoregulation of Blood Flow in the Human Retina, Optic Nerve, and Choroid in Response to Acute Decrease in Intraocular Pressure Using Novel Vacuum Goggles
Investigative Ophthalmology & Visual Science, 61(7), 1735, 2020.
Zaidoon Y Alshare, Ryuya Hashimoto and Randy Kardon
Reduced Blood Flow in the Choroidal Watershed and Parapapillary Hypoperfusion Zones and Relation to Optic Disc Blood Flow
Investigative Ophthalmology & Visual Science, 61(7), 1744, 2020.
Michelle R. Tamplin, Kimberly A. Broadhurst, Anthony H. Vitale, Ryuya Hashimoto, Randy H. Kardon and Isabella M. Grumbach
Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy
Translational vision science & technology, 10(2), 16-16, doi:10.1167/tvst.10.2.16, 2021.
Jui-Kai Wang, Michelle R. Tamplin, Mona K. Garvin, Isabella M. Grumbach and Randy H. Kardon
A superpixel-histogram method to analyze retinal, optic nerve, and choroidal blood flow using laser speckle flowgraphy
Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1203622, doi:10.1117/12.2611850, 2022.
Noriyoshi Takahashi, Jui-Kai Wang, Edward F. Linton, Noor-Us-Sabah Ahmad, Julie K. Nellis, Mona K. Garvin and Randy H. Kardon
Automated Optic Disc Finder and Segmentation Using Deep Learning for Blood Flow Studies in the Eye
International Workshop on Ophthalmic Medical Image Analysis, 112-121, doi:10.1007/978-3-031-44013-7_12, 2023.

Department of Health and Human Physiology, University of Iowa

Seth W. Holwerda, Randy H. Kardon, Ryuya Hashimoto, Jan M. Full, Julie K. Nellis, Lyndsey E. DuBose, Jess G. Fiedorowicz, and Gary L. Pierce
Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults
Journal of Applied Physiology, doi: 10.1152/japplphysiol.00252.2020, 2020.

Department of Radiation Oncology, University of Iowa

Michelle R.Tamplin, Kimberly A.Broadhurst, Anthony H.Vitale, Ryuya Hashimoto, Randy H.Kardon and Isabella M.Grumbach
Measuring hyperemic response to light flicker stimulus using continuous laser speckle flowgraphy in mice
Experimental Eye Research, 216, 108952, doi:10.1016/j.exer.2022.108952, 2022.
Michelle R. Tamplin, Jui‑Kai Wang, Anthony H. Vitale, Ryuya Hashimoto, Mona K. Garvin, Elaine M. Binkley, Daniel E. Hyer, John M. Buatti, H. Culver Boldt, Randy H. Kardon and Isabella M. Grumbach
Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma
BMC ophthalmology, 22, 285, doi:10.1186/s12886-022-02505-9, 2022.

The University of Iowa Hospital and Clinics

Matthew T Jones, Sebastian Sanchez, Rishi R Patel, Jacob M Miller, Ashrita Raghuram, Randy Kardon and Edgar Samaniego
Abstract Number - 255: Laser Speckle Flowgraphy As A Surrogate Marker For Symptomatic Carotid Stenosis
Stroke: Vascular and Interventional Neurology, 3(S1), e12677, 2023.
Matthew T Jones, Sebastian Sanchez, Rishi R Patel, Ashrita Raghuram, Jacob M Miller, Ryuya Hashimoto, Randy Kardon and Edgar A Samaniego
Evaluation of ocular blood flow in the assessment of symptomatic carotid stenosis
Interventional Neuroradiology, doi:10.1177/15910199231169844, 2023.

Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School

Rachelle Koch, Brendan Seto, Keiko Yamada, Purva Atreay, Colin A. Lemire, Nina Hazra and Jorge G. Arroyo
Relative Retinal Blood Flow: A Novel and Informative Measure of Unilateral Retinal Vein Occlusion Severity
Translational Vision Science & Technology, 10(3), 15-15, doi:10.1167/tvst.10.3.15, 2021.
Shashvat Chandrakant Purohit, Colin A Lemire, Brendan Seto, Keiko Yamada and Jorge G Arroyo
Relative Retinal Blood Flow in Patients with Central Retinal Artery Occlusions
Investigative Ophthalmology and Visual Science, 62(8), 3197, 2021 ARVO Annual Meeting abstract, 2021.

The Children's Hospital of Philadelphia

Robert A Avery, Tomas S Aleman, Gui-Shuang Ying, Yinxi Yu, Arielle Garcia and Moe Hein Aung
Effect of dark adaptation and fixation lights on macular blood flow as determined by laser speckle flowgraphy
Investigative Ophthalmology and Visual Science, 64(8), 1995, 2023 ARVO Annual Meeting abstract, 2023.

Departments of Neurology, The Perelman School of Medicine at the University of Pennsylvania

Moe H. Aung, Tomas S. Aleman, Arielle S. Garcia, Brendan McGeehan, Gui-Shuang Ying and Robert A. Avery
Stimulus type and duration affect magnitude and evolution of flicker-induced hyperemia measured by laser speckle flowgraphy at the optic disc and peripapillary vessels
Scientific Reports, 14, 6659, doi:10.1038/s41598-024-57263-z, 2024.

Department of Clinical Pharmacology, Medical University of Vienna

P.A. Wozniak, N. Luft, G. Aschinger, K. Fondi, A.M. Bata, K.J. Witkowska, D. Schmidl, R.M. Werkmeister, M. Bolz, G. Garhöfer and L. Schmetterer
The assessment of ocular blood flow with laser speckle flowgraphy in healthy caucasian.
Acta Ophthalmologica, 2016, 94.S256. doi: 10.1111/j.1755-3768.2016.0391
Nikolaus Luft, Piotr A. Wozniak, Gerold C. Aschinger, Klemens Fondi, Ahmed M. Bata, René M. Werkmeister, Doreen Schmidl, Katarzyna J. Witkowska, Matthias Bolz, Gerhard Garhöfer and Leopold Schmetterer
Measurements of Retinal Perfusion Using Laser Speckle Flowgraphy and Doppler Optical Coherence Tomography
IOVS, 57(13), 5417-5425, 2016.
Nikolaus Luft, Piotr A. Wozniak, Gerold C. Aschinger, Klemens Fondi, Ahmed M. Bata, René M. Werkmeister, Doreen Schmidl, Katarzyna J. Witkowska, Matthias Bolz, Gerhard Garhöfer and Leopold Schmetterer
Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy
PLOS ONE, 11(12), e0168190, 2016.
D.Schmidl, K.Witkowska, N.Luft, M.Bolz, K.Fondi, A.Bata, P.Wozniak, R.Werkmeister, G.Garhofer and L.Schmetterer
Assessment of retinal blood flow using Laser Speckle Flowgraphy
Acta Ophthalmologica, 95.S259, doi: 10.1111/j.1755-3768.2017.01145, 2017.
Katarzyna J. Witkowska, Ahmed M. Bata, Giacomo Calzetti, Nikolaus Luft, Klemens Fondi, Piotr A. Wozniak, Doreen Schmidl, Matthias Bolz, Alina Popa-Cherecheanu, René M. Werkmeister, Gerhard Garhöfer and Leopold Schmetterer
Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy
PLOS ONE, 12(9), e0184772, doi: 10.1371/journal.pone.0184772, 2017.
Giacomo Calzetti, Klemens Fondi, Ahmed M Bata, Nikolaus Luft, Piotr A Wozniak, Katarzyna J Witkowska, Matthias Bolz, Alina Popa-Cherecheanu, René M Werkmeister, Doreen Schmidl, Gerhard Garhöfer and Leopold Schmetterer
Assessment of choroidal blood flow using laser speckle flowgraphy
British Journal of Ophthalmology, bjophthalmol-2017-311750, doi: 10.1136/bjophthalmol-2017-311750, 2018.
Fondi K, Bata AM, Luft N, Witkowska KJ, Werkmeister RM, Schmidl D, Bolz M, Schmetterer L and Garhöfer G
Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy.
PLOS ONE, 13(11), e0207525, doi:10.1371/journal.pone.0207525, 2018.
Theresa Lindner, Nikolaus Hommer, Martin Kallab, Andreas Schlatter, Clemens Nadvornik, Patrick Janku, Victoria Kauer, Benedikt Rumpf, Helmuth Haslacher, Gerhard Garhöfer and Doreen Schmidl
Retinal blood flow and oxygen saturation in patients previously infected with COVID-19
Acta Ophthalmologica, doi: 10.1111/j.1755-3768.2022.0088, 2022.
Anton B Hommer, Viktoria Pai, Patrick Janku, Theresa Lindner, Liudmyla Pylypenko, Leopold Schmetterer, Gerhard Garhofer and Doreen Schmidl
A new approach for measuring retinal oxygen extraction based on laser speckle flowgraphy and retinal oximetry
Investigative Ophthalmology and Visual Science, 64(8), 4738, 2023 ARVO Annual Meeting abstract, 2023.

Department for Ophthalmology, Kepler University Hospital

Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study.
Scientific Reports, 8(1), 5343, doi:10.1038/s41598-018-23149-0, 2018.
Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
Short-term effect on the ocular circulation inducedby unilateral intravitreal injection of aflibercept inage-related maculopathy
Acta Ophthalmologica, doi:10.1111/aos.14098, 2019.
Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
Differences in Optic Nerve Head Blood Flow Regulation in Normal Tension Glaucoma Patients and Healthy Controls as Assessed with Laser Speckle Flowgraphy During the Water Drinking Test
Journal of Glaucoma, doi:10.1097/IJG.0000000000001258, 2019.
Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer and Matthias Bolz
Effects of three intravitreal injections of aflibercept on the ocular circulation in eyes with age-related maculopathy
British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2019-313919, 2019.
A.S. Mursch-Edlmayr, L. Pickl, G. Calzetti, K. Waser, J. Wendelstein, S. Beka, V. Aranha dos Santos, N. Luft, L. Schmetterer and M. Bolz
Comparison of neurovascular coupling between normal tension glaucoma patients and healthy individuals with Laser Speckle Flowgraphy.
Current eye research, doi: 10.1080/02713683.2020.1752390, 2020.

Ophthalmology Unit, University Hospital of Parma

Giacomo Calzetti, Paolo Mora, Stefania Favilla, Giorgia Ottonelli, Giulia Devincenzi, Arturo Carta, Salvatore Tedesco, Anna Mursch-Edlmayr, Gerhard Garhöfer, Stefano Gandolfi, Leopold Schmetterer
Assessment of Choroidal Neovascularization Perfusion: A Pilot Study With Laser Speckle Flowgraphy
Translational Vision Science & Technology, 9(5), 9, doi: 10.1167/tvst.9.5.9, 2020.
Giacomo Calzetti, Federica Angella, Alice Galli, Giada Marcantoni, Alessandro Romani, Mariabeatrice Simonelli, Paolo Mora, Stefano A Gandolfi, Leopold Schmetterer and Arturo Carta
Longitudinal changes in optic nerve head perfusion in non-arteritic anterior ischemic optic neuropathy
Investigative Ophthalmology & Visual Science, 61(7), 3951, 2020.
Giacomo Calzetti, Paolo Mora, Alessandro Romani, Giorgia Ottonelli, Alessandra Pareti, Stefano Gandolfi, Leopold Schmetterer and Arturo Carta
Optic nerve head and peripapillary perfusion as assessed with laser speckle flowgraphy in non-arteritic anterior ischaemic optic neuropathy
Acta Ophthalmologica, 99(3), e445-e446, doi:10.1111/aos.14555, 2020.
Giacomo Calzetti, Anna Sophie Mursch-Edlmayr, Ahmed M. Bata, Nicola Ungaro, Paolo Mora, Jacqueline Chua, Doreen Schmidl, Matthias Bolz, Gerhard Garhöfer, Stefano Gandolfi, Leopold Schmetterer and Damon Wong
Measuring optic nerve head perfusion to monitor glaucoma: a study on structure-function relationships using laser speckle flowgraphy.
Acta Ophthalmologica, doi:10.1111/aos.14862, 2021.
Giacomo Calzetti, Paolo Mora, Enrico Borrelli, Riccardo Sacconi, Guido Ricciotti, Arturo Carta, Stefano Gandolfi and Giuseppe Querques
Short-term changes in retinal and choroidal relative flow volume after anti-VEGF treatment for neovascular age-related macular degeneration
Scientific Reports, 11(1), 1-7, 23723, doi:10.1038/s41598-021-03179-x, 2021.
Matilde Longhena, Carlo Bellucci, Elisabetta Delfini, Alessandra Pareti, Stefano Gandolfi and Paolo Mora
One-year follow up of a tobacco alcohol optic neuropathy case with atypical course: Conventional assessment and Laser speckle flowgraphy
European Journal of Ophthalmology, doi:10.1177/11206721231160958, 2023.

Institute of Molecular and Clinical Ophthalmology Basel

Giacomo Calzetti, Chiara La Morgia, Marco Cattaneo, Arturo Carta, Francesca Bosello, Giulia Amore, Michele Carbonelli, Maria Lucia Cascavilla, Stefano Gandolfi, Valerio Carelli, Leopold Schmetterer, Hendrik P. N. Scholl and Piero Barboni
Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy
Investigative Ophthalmology and Visual Science, 63(1), 43, doi:10.1167/iovs.63.1.43, 2022.
Barbara Swiatczak, Giacomo Calzetti and Frank Schaeffel
Axial length changes induced by positive defocus correlate with changes in choroidal blood flow
Investigative Ophthalmology and Visual Science, 63(7), 406, 2022 ARVO Annual Meeting abstract, 2022.
Barbara Swiatczak, Frank Schaeffel and Giacomo Calzetti
Imposed positive defocus changes choroidal blood flow in young human subjects
Graefe's Archive for Clinical and Experimental Ophthalmology, 261, 115-125, doi:10.1007/s00417-022-05842-z, 2022.
Barbara Swiatczak
Ocular blood flow and myopia
Acta Ophthalmologica, doi:10.1111/j.1755-3768.2022.0088, 2022.

Department of Ophthalmology, University of Zurich

Anahita Bajka, Nastasia Foa, Sophia Sidhu, Magdalena Rejdak, Sadiq Said, Maximilian Robert Justus Wiest, Timothy Hamann, Frank Blaser and Sandrine Anne Zweifel
Analysis of Blood Flow in the Macula and Optic Nerve Head in Healthy Young Volunteers Using Laser Speckle Flowgraphy
Klinische Monatsblätter für Augenheilkunde, 240(04), 608-612, doi:10.1055/a-2026-0924, 2023.

Ophthalmology Clinic, Department of Medicine and Science of Ageing, University "G. d' Annunzio"

Lisa Toto, Federica Evangelista, Pasquale Viggiano, Emanuele Erroi, Giada D'Onofrio, Daniele Libertini, Annamaria Porreca, Rossella D'Aloisio, Parravano Mariacristina, Luca Di Antonio, Marta Di Nicola and Rodolfo Mastropasqua
Changes in Ocular Blood Flow after Ranibizumab IntravitrealInjection for Diabetic Macular Edema Measured Using LaserSpeckle Flowgraphy
BioMed Research International, 2020, 9496242, doi:10.1155/2020/9496242, 2020.

Lipoapheresis Unit, Fondazione Toscana "Gabriele Monasterio"

T. Sampietro, B. Dal Pino, F. Bigazzi, F. Sbrana, A. Ripoli, E. Fontanelli, M. Pianelli, R. Luciani, A. Lepri and G. Calzetti
Ocular microcirculation blood flow acutely increases upon cholesterol removal. The eyes mirror of the heart?
Atherosclerosis, 355, 38-39, doi:j.atherosclerosis.2022.06.340, 2022.
T. Sampietro, B. Dal Pino, F. Bigazzi, F. Sbrana, A. Ripoli, E. Fontanelli, M. Pianelli, R. Luciani, A. Lepri and G. Calzetti
Acute Increase in Ocular Microcirculation Blood Flow Upon Cholesterol Removal. The Eyes Are the Window of the Heart
The American Journal of Medicine, 136(1), 108-114, doi:10.1016/j.amjmed.2022.08.016, 2022.

Department of Ophthalmology, Rigshospitalet

Jakob Wågström, Lasse Malmqvist and Steffen Hamann
Optic Nerve Head Blood Flow Analysis in Patients with Optic Disc Drusen Using Laser Speckle Flowgraphy
Neuro-Ophthalmology, doi:10.1080/01658107.2020.1795689, 2020.

Ophthalmology, University Medical Center Groningen

Konstantinos Pappelis, Lars Choritz and Nomdo Jansonius
Microcirculatory model predicts blood flow and autoregulation range in the human retina: in vivo investigation with Laser Speckle Flowgraphy
American Journal of Physiology-Heart and Circulatory Physiology, doi:10.1152/ajpheart.00404.2020, 2020.

Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital

X. Wei, A. Barathi, B.B. Sai, P.K. Balne, N. Khandelwal and R. Agrawal
Assessment of chorioretinal blood flow and vessel diameter by laser speckle flowgraphy in three animal models
Acta Ophthalmologica, 2016, 94.S256. doi: 10.1111/j.1755-3768.2016.0566

Universiti Teknologi PETRONAS

M. S. Bhatti, W. Rasheed, T. B. Tang and A. Laude
Investigating eye-strain due to prolonged exposure to low resolution multimedia using LSFG
2016 6th International Conference on Intelligent and Advanced Systems (ICIAS), doi:10.1109/ICIAS.2016.7824096, 2016.
Mehwish Saba Bhatti, Tong Boon Tang and Augustinus Laude
Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
PLoS ONE 12(7): e0181512. doi:10.1371/journal.pone.0181512, 2017.
Mehwish Saba Bhatti, Tong Boon Tang and Hui Cheng Chen
Ocular Blood Flow in Rabbits under Deep Anesthesia: A Real-Time Measurement Technique and Its Application in Characterizing Retinal Ischemia
Scientific Reports, 8(1), 5713, doi:10.1038/s41598-018-24141-4, 2018.
Aishah Ismail, Mehwish S. Bhatti, Ibrahima Faye, Cheng Kai Lu, Augustinus Laude and Tong Boon Tang
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
Graefe's Archive for Clinical and Experimental Ophthalmology, doi: 10.1007/s00417-018-4030-9, 2018.
Aishah Ismail, Tong Boon Tang, Faye Ibrahima and Chen Hui Cheng
Animal Model - Investigation of Laser Speckle Flowgraphy for Early Carotid Artery Stenosis Detection
2018 International Conference on Intelligent and Advanced System (ICIAS), doi:10.1109/ICIAS.2018.8540566, 2018.
Aishah Ismail, Hui Cheng Chen, Ibrahima Faye and Tong Boon Tang
Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
Scientific Reports, 10(1), 15829, doi:10.1038/s41598-020-72556-9, 2020.

Singapore Eye Research Institute

Sai Bo Bo Tun, Veluchamy Amutha Barathi
Akimba Proliferative Diabetic Retinopathy Model: Understanding Molecular Mechanism and Drug Screening for the Progression of Diabetic Retinopathy
Methods in Molecular Biology, 2678, 13-26, doi:10.1007/978-1-0716-3255-0, 2023.

Taipei Medical University

Yen-Ju Chan, Po-Lin Liao, Chi-Hao Tsai, Yu-Wen Cheng, Fan-Li Lin, Jau-Der Ho, Ching-Yi Chen and Ching-Hao Li
Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
Particle and fibre toxicology, 18(1), 1-16, doi:10.1186/s12989-020-00395-7, 2021.
Fan-Li Lin, Yu-Wen Cheng, Li-Huei Chen, Jau-Der Ho, Jing-Lun Yen, Mong-Heng Wang, Tzong-Huei Lee and George Hsiao
Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity
Biomedicine and Pharmacotherapy, 158, 114138, doi:10.1016/j.biopha.2022.114138, 2022.

Department of Ophthalmology, Chang Gung Memorial Hospital

Margaret Ming-Chih Ho, Yueh-Ju Tsai, Yen-Chang Chu and Yi-Lin Liao
Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease
BioMed Research International, doi:10.1155/2022/9115270, 2022.
Tsung‑Ying Tsai, Yueh‑Ju Tsai, Yen‑Chang Chu, Yih‑Shiou Hwang and Yi‑Lin Liao
Ocular circulation change in optic disc melanocytoma – a case report and a review of the literature
BMC ophthalmology, 23(1), 1-8, doi:10.1186/s12886-023-02785-9, 2023.

Department of Ophthalmology, College of Medicine, King Saud University

Ahmed M. Abu El-Asrar, Waleed Alsarhani, Abdullah Alzubaidi and Priscilla W. Gikandi
Effect of immunosuppressive therapy on ocular blood flow in initial-onset acute uveitis associated with Vogt–Koyanagi–Harada disease.
Acta Ophthalmologica, doi:10.1111/aos.14842, 2021.
Ahmed M. Abu El-Asrar, Abdulrahman F. AlBloushi, Priscilla W. Gikandi, Abdullah Alzubaidi and Einar Stefánsson
Changes in ocular blood flow and retinal oxygen metabolism during immunosuppressive therapy for initial-onset acute uveitis associated with Vogt–Koyanagi–Harada disease
Acta Ophthalmologica, doi:10.1111/aos.15122, 2022.
Ahmed M. Abu El-Asrar, Abdulrahman F. AlBloushi, Priscilla W. Gikandi, Abdullah Alzubaidi and Einar Stefánsson
Acute uveitic phase of Vogt-Koyanagi-Harada disease: optic nerve head swelling, ocular blood flow and retinal oxygen metabolism
Eye, doi:10.1038/s41433-022-02141-z, 2022.
Waleed K. Alsarhani, Fadwa F. Al Adel, Abdullah Alamri, Rahaf M. Al Malawi and Abdulrahman F. AlBloushi
Alterations in ocular microcirculation and oxygen metabolism in patients with lipemia retinalis
BMC Ophthalmology, 22, 295, doi:10.1186/s12886-022-02515-7, 2022.

Senju Pharmaceutical Co.,Ltd

Hiroaki Takahashi, Tetsuya Sugiyama, Hideki Tokushige, Takatoshi Maeno, Toru Nakazawa, Tsunehiko Ikeda, Makoto Araie
Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits
Experimental Eye Research(2012), http://dx.doi.org/10.1016/j.exer.2012.12.003

Department of Computer Science and Electronics, Kyushu Institute of Technology

H.Fujii
Visualization of retinal blood flow by laser speckle flowgraphy
Med. Bio. Eng. & Comp., 32, no.3, 302-304, 1994.
Naoki Konishi, Hitoshi Fujii
Real-time Visualization of retinal microcirculation by laser flowgraphy
Optical Enginnering, 34, no.3,753-757, 1995.
H. Fujii, N. Konishi, K. Okamoto and Y. Tsuchihashi
Evaluation of Retinal Microcirculation by Real-Time Laser Flowgraphy
Proc. 2nd Internet Ocular Blood Circulation Symposium, 1995.
Hitoshi Fujii and Naoki Konishi
Visualization of Blood Flow Using Laser Speckle Method
Proceedings of 18th Annual International Conference, No.688 1996.
Hitoshi Fujii Yoshihiko Tsuchihashi and Naoki Konishi
Evaluation of Retinal Microcirculation by Real-Time Laser Flowgraphy(II)
Proc. 3rd Internet World Congress on Biomedical Sciences, 1996
Hitoshi Fujii
Laser Speckle Blood Flowgraphy Medical Diagnostic Techniques and Procedures, Megha Singh et.al. Ed.,
216-224 (Narosa Publishing House, New Delhi, London, 1999)
Naoki Konishi, Yoshinori Tokimoto, Kazuhiro Kohra and Hitoshi Fujii
New Laser Speckle Flowgraphy System Using CCD Camera
Optical Review, 9, No.4, 163-169, 2002
Min-Chul Lee, Naoki Konishi and Hitoshi Fujii
Blood Flow Analyses of Skin Tissue Under the Sacrum Using Laser Speckle Flowgraphy
Optical Review, 10, No. 6, 562-566, 2003
Kenji Okamoto, Noriyoshi Takahashi, Tatsuhiko Kobayashi, Tomoaki Shiba, Yuichi Hori and Hitoshi Fujii
Novel superpixel method to visualize fundus blood flow resistivity in healthy adults
Scientific Reports, 13, doi:10.1038/s41598-023-33450-2, 2023.

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